Lu AE98134|cas:849000-18-6|西域试剂

Lu AE98134,98.37%

产品编号：Bellancom-133910| CAS NO：849000-18-6| 分子式：C₂₁H₂₃N₅O₃S| 分子量：425.50

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货号	价格	库存与货期
Bellancom-133910	￥3500.00	杭州北京（现货）
Bellancom-133910	￥5800.00	杭州北京（现货）
Bellancom-133910	￥10500.00	杭州北京（现货）
Bellancom-133910	￥16500.00	杭州北京（现货）
Bellancom-133910	￥26000.00	杭州北京（现货）

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Lu AE98134

产品介绍

Lu AE98134 是电压门控钠通道 (voltage-gated sodium channels) 的激活剂，作为 Na_v1.1 通道的部分选择性激活剂。Lu AE98134 也可以增加 Na_v1.2 和 Na_v1.5 通道的活性，但对 Na_v1.4、Na_v1.6 和 Na_v1.7 通道活性无明显影响。Lu AE98134 可用于分析 Na_v1.1 通道在各种中枢神经系统疾病中的病理生理功能，如精神分裂症等。

生物活性

Lu AE98134, an activator of voltage-gated sodium channels, acts as a partly selective Na_v1.1 channels positive modulator. Lu AE98134 also increases the activity of Na_v1.2 and Na_v1.5 channels but not of Na_v1.4, Na_v1.6 and Na_v1.7 channels. Lu AE98134 can be used to analyze pathophysiological functions of the Na_v1.1 channel in various central nervous system diseases, including cognitive restoring in schizophrenia, et al.

体外研究

Lu AE98134 (30 μM) promotes the current mediated by Nav_v1.1 channel, and it activates Na_v1.5 and to a lesser extent Na_v1.2 but has no effect on Na_v1.4, Na_v1.6 and Na_v1.7 currents in HEK cells expressing Na_v1.1, Na_v1.2, Na_v1.6, Na_v1.5, and Na_v1.7 by step-wise depolarizing voltages using the whole-cell patchclamp configuration.
Lu AE98134 (30 μM) increases the excitability of FSINs by decreasing the threshold for action potentials.Intracellular depolarizing current pulses evokes repetitive firing of action potentials at frequencies, additionally, Lu AE98134 increases the excitability since each current pulse generated a higher number of spikes (163 spikes in control; and 230 spikes in Lu AE98134).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

The fast spiking inhibitory interneurons (FSINs) from Dlx5/6^+/− animals exhibit abnormal excitability because of a more depolarized spike threshold and broader action potentials.
Lu AE98134 (30 μM) increases the excitability of FSINs neurons from normal and Dlx5/6^+/− animals by modulating several parameters characteristic for NaV_1.1 channels. The selective activation of FSINs by Lu AE98134 restores cognitive flexibility in adult Dlx5/6^+/− mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 250 mg/mL (587.54 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3502 mL	11.7509 mL	23.5018 mL
5 mM	0.4700 mL	2.3502 mL	4.7004 mL
10 mM	0.2350 mL	1.1751 mL	2.3502 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.08 mg/mL (4.89 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.89 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.08 mg/mL (4.89 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (4.89 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。