Pentoxyverine Carbetapentane,98.37%
产品编号:Bellancom-134004| CAS NO:77-23-6| 分子式:C20H31NO3| 分子量:333.47
戊氧维林(卡贝塔戊烷)是一种sigma-1受体激动剂,在豚鼠脑膜上的Ki为75 nM。戊氧维林是一种中枢作用的止咳药,具有抗霉素和抗惊厥特性。戊氧维林可用于抑制支气管阻滞剂、减弱咳嗽反射、支气管平滑肌松弛和降低气道阻力。
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Pentoxyverine Carbetapentane
产品介绍 | Pentoxyverine (Carbetapentane) 是 sigma-1 受体激动剂,在豚鼠脑膜上的 Ki 值为 75 nM。Pentoxyverine 是一种中枢性咳嗽抑制剂,具有抗毒蕈碱和抗惊厥作用。Pentoxyverine 可用于抑制支气管阻滞剂,减弱咳嗽反射,支气管平滑肌松弛和降低气道阻力。 | ||||||||||||||||
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生物活性 | Pentoxyverine (Carbetapentane) is a sigma-1 receptor agonist, with a Ki of 75 nM on guinea-pig brain membranes. Pentoxyverine is a centrally-acting cough suppressant with antimuscarinic and anticonvulsant properties. Pentoxyverine can be used for inhibiting bronchial interceptor, weakening of cough reflex, bronchial smooth muscle relaxation and reduction of airway resistance[4]. | ||||||||||||||||
体外研究 |
Pentoxyverine competitive binds to [3H]-pentazocine-labelled sites on guinea-pig brain membranes, with a Ki of 75 nM[4]. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||||||
体内研究 |
Pentoxyverine (1-5 mg/kg; a single i.p.) inhibits citric-acid-induced cough in guinea-pigs[4]. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||||||
体内研究 |
Pentoxyverine (1-5 mg/kg; a single i.p.) inhibits citric-acid-induced cough in guinea-pigs[4]. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||||||
性状 | Solid | ||||||||||||||||
溶解性数据 |
In Vitro:
DMSO : 250 mg/mL (749.69 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂:
——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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参考文献 |
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安全声明 (欧洲) | S26-S36 |
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WGK德国 | 3 |
海关编码 | 2921300090 |
~% ![]() 77-23-6 |
文献:US2842585 , ; |
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