YNT-185 dihydrochloride|cas:1804978-82-2|西域试剂

YNT-185 dihydrochloride,99.39%

产品编号：Bellancom-136181| CAS NO：1804978-82-2| 分子式：C₃₃H₃₉Cl₂N₅O₅S| 分子量：688.66

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-136181		￥1800.00	杭州北京（现货）

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YNT-185 dihydrochloride

产品介绍

YNT-185 dihydrochloride 是一中非肽类的，选择性食欲素 2 型受体 (OX2R) 激动剂，对 OX2R 和 OX1R 的 EC₅₀ 分别为 0.028 和 2.75 μM。YNT-185 dihydrochloride 改善小鼠模型的发作性瘫痪症状。

生物活性

YNT-185 dihydrochloride is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC₅₀s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 dihydrochloride ameliorates narcolepsy-cataplexy symptoms in mouse models.

体外研究

体内研究

YNT-185 dihydrochloride (20-40 mg/kg; i.p.) increases wakefulness in mice.
YNT-185 dihydrochloride (300 nmol; i.c.v.) significantly increases wake time for 3 hours in a dose-dependent manner, accompanied by a decrease in NREM sleep time, in wild-type mice but not in OXRDKO mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male wild-type C57BL/6J mice
Dosage:	20, 40 mg/kg
Administration:	I.p.
Result:	Wake time was also significantly increased.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male wild-type C57BL/6J mice
Dosage:	20, 40 mg/kg
Administration:	I.p.
Result:	Wake time was also significantly increased.

性状

Solid

溶解性数据

In Vitro:

DMSO : 125 mg/mL (181.51 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.4521 mL	7.2605 mL	14.5210 mL
5 mM	0.2904 mL	1.4521 mL	2.9042 mL
10 mM	0.1452 mL	0.7260 mL	1.4521 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献