(Thr4,Gly7)-Oxytocin|cas:60786-59-6|西域试剂

(Thr4,Gly7)-Oxytocin,99.90%

产品编号：Bellancom-P3467| CAS NO：60786-59-6| 分子式：C₃₉H₆₁N₁₁O₁₂S₂| 分子量：940.10

催产素类似物（Thr4，Gly7）-催产素是一种特异性OT受体激动剂。（Thr4，Gly7）-催产素还可通过激活TRPV1通道和抑制K+通道来刺激皮层下神经元。.

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-P3467	￥2000.00	杭州北京（现货）
Bellancom-P3467	￥3500.00	杭州北京（现货）
Bellancom-P3467	￥6500.00	杭州北京（现货）
Bellancom-P3467	￥9500.00	杭州北京（现货）
Bellancom-P3467	￥13500.00	杭州北京（现货）

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(Thr4,Gly7)-Oxytocin

产品介绍

(Thr4,Gly7)-Oxytocin, 一种催产素 (Oxytocin) 类似物，是一种特异性 OT 受体 激动剂。(Thr4,Gly7)-Oxytocin 还可通过激活 TRPV1 通道和抑制 K⁺ 通道来诱导眼下神经元兴奋。

生物活性

(Thr4,Gly7)-Oxytocin, an Oxytocin analogue, is a specific OT receptor agonist. (Thr4,Gly7)-Oxytocin also excites subicular neurons via activation of TRPV1 channels, and depression of K⁺ channels. .

体外研究

(Thr4,Gly7)-Oxytocin (1 μM, 1 min) evokes an inward current of 5.9 pA in paraventricular thalamus (PVT) neurons.
(Thr4,Gly7)-Oxytocin (1 μM, 1 min) increases spontaneous excitatory postsynaptic currents (sEPSCs) frequency in PVT neurons.
(Thr4,Gly7)-Oxytocin (0.3 μM, 5 min) induces depolarization in both bursting cells and regular firing cells.
(Thr4,Gly7)-Oxytocin (0.3 μM, 5 min) depolarizes subicular neurons by activating TRPV1 channels.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

(Thr4,Gly7)-Oxytocin (1 μM, direct intra-PVT infusion for 1 min) evokes depolarization on TGOT-responsive neurons in mice.
(Thr4,Gly7)-Oxytocin (100 ng, intracerebroventrical injection) increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Swiss Webster mice
Dosage:	1 μM
Administration:	Intratracheal administration for 24 h
Result:	Excited 34.3% of aPVT neurons, 57.6% of mPVT neurons, and 60.0% of pPVT neurons. Increased the firing rate of TGOT-responsive PVT neurons in all subregions.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Swiss Webster mice
Dosage:	1 μM
Administration:	Intratracheal administration for 24 h
Result:	Excited 34.3% of aPVT neurons, 57.6% of mPVT neurons, and 60.0% of pPVT neurons. Increased the firing rate of TGOT-responsive PVT neurons in all subregions.

性状

Solid

溶解性数据

In Vitro:

H₂O : 100 mg/mL (106.37 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.0637 mL	5.3186 mL	10.6372 mL
5 mM	0.2127 mL	1.0637 mL	2.1274 mL
10 mM	0.1064 mL	0.5319 mL	1.0637 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献

. Lily R Barrett, et al. Oxytocin activation of paraventricular thalamic neurons promotes feeding motivation to attenuate stress-induced hypophagia. Neuropsychopharmacology. 2021 Apr;46(5):1045-1056. [Content Brief]

. Binqi Hu, et al. Activation of Oxytocin Receptors Excites Subicular Neurons by Multiple Signaling and Ionic Mechanisms. Cereb Cortex. 2021 Mar 31;31(5):2402-2415. [Content Brief]

. M R Melis, et al. Oxytocin increases nitric oxide production in the paraventricular nucleus of the hypothalamus of male rats: correlation with penile erection and yawning. Regul Pept. 1997 Mar 26;69(2):105-11. [Content Brief]

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产品编号(Item Number)

批号(Lot Number)

危害码 (欧洲)	Xn
风险声明 (欧洲)	20
安全声明 (欧洲)	36/37/39-45

(Thr4,Gly7)-Oxytocin,99.90%

(Thr4,Gly7)-Oxytocin

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