Pipecuronium bromide 哌库溴铵|cas:52212-02-9|西域试剂

Pipecuronium bromide 哌库溴铵,98.71%

产品编号：Bellancom-B0743A| CAS NO：52212-02-9| 分子式：C₃₅H₆₂Br₂N₄O₄| 分子量：762.70

Pipecuronium bromide 是一种有效的长效非去极化甾体神经肌肉阻滞剂 (NMBA)，是一种双季铵化合物。Pipecuronium bromide 是一种功能强大的竞争性 nAChR 拮抗剂，Kd 为 3.06 μM。

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货号	价格	库存与货期
Bellancom-B0743A	￥1000.00	杭州北京（现货）
Bellancom-B0743A	￥1600.00	杭州北京（现货）
Bellancom-B0743A	￥3200.00	杭州北京（现货）
Bellancom-B0743A	￥5100.00	杭州北京（现货）
Bellancom-B0743A	￥8200.00	杭州北京（现货）

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Pipecuronium bromide 哌库溴铵

产品介绍

Pipecuronium bromide 是一种有效的长效非去极化甾体神经肌肉阻滞剂 (NMBA)，是一种双季铵化合物。Pipecuronium bromide 是一种功能强大的竞争性 nAChR 拮抗剂，Kd 为 3.06 μM。

生物活性

Pipecuronium bromide is a potent long-acting nondepolarizing steroidal neuromuscular blocking agent (NMBA), and a bisquaternary ammonium compound. Pipecuronium bromide is a powerful competitive nAChR antagonist with a Kd of 3.06 μM^[4]^[5].

体外研究

Sugammadex has a high affinity for Pipecuronium bromide. As Pipecuronium bromide is about 6 to 7 times more potent than Rocuronium, fewer molecules are required to achieve a comparative blockade than in the case of Rocuronium.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

The average ED₉₅ is 0.045mg/kg (0.035-0.059 mg/kg) of Pipecuronium bromide, the onset of action varies between 2 and 6.3 minutes, depending on the dose and the background anesthesia. Pipecuronium bromide does not liberate histamine, it has no cardiovascular side effects even in doses of 3× ED₉₅, and anaphylaxis does not appear to be a problem.
Carboxymethylated γ-cyclodextrin shows efficient and complete reversal of the Pipecuronium bromide induced neuromuscular block in an ex vivo rat diaphragm experiment.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 150 mg/mL (196.67 mM; Need ultrasonic)

H₂O : 100 mg/mL (131.11 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.3111 mL	6.5557 mL	13.1113 mL
5 mM	0.2622 mL	1.3111 mL	2.6223 mL
10 mM	0.1311 mL	0.6556 mL	1.3111 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献

. Tassonyi E, et al. Reversal of Pipecuronium-Induced Moderate Neuromuscular Block with Sugammadex in the Presence of a Sevoflurane Anesthetic: A Randomized Trial. Anesth Analg. 2015 Aug;121(2):373-80. [Content Brief]

. Tassonyi E, et al. Reversal of Deep Pipecuronium-Induced Neuromuscular Block With Moderate Versus Standard Dose of Sugammadex: A Randomized, Double-Blind, Noninferiority Trial. Anesth Analg. 2018 Dec;127(6):1344-1350. [Content Brief]

. Alánt O, et al. First clinical experience with a new neuromuscular blocker pipecurium bromide. Arzneimittelforschung. 1980;30(2a):374-9. [Content Brief]

[4]. Töröcsik A, et al. Characterization of somatodendritic neuronal nicotinic receptors located on the myenteric plexus. Eur J Pharmacol. 1991 Sep 24;202(3):297-302. [Content Brief]

[5]. Kárpáti E, et al. Investigation of neuromuscular blocking agents at Richter Ltd. Acta Pharm Hung. 2002;72(1):37-48. [Content Brief]

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