NS-102|cas:136623-01-3|西域试剂

NS-102,98.23%

产品编号：Bellancom-114427| CAS NO：136623-01-3| 分子式：C₁₂H₁₁N₃O₄| 分子量：261.23

NS-102是一种选择性红藻氨酸（GluK2）受体拮抗剂。NS-102是一种有效的GluR6/7受体拮抗剂。

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货号	价格	库存与货期
Bellancom-114427	￥4800.00	杭州北京（现货）
Bellancom-114427	￥8000.00	杭州北京（现货）
Bellancom-114427	￥15500.00	杭州北京（现货）
Bellancom-114427	￥24000.00	杭州北京（现货）
Bellancom-114427	￥36000.00	杭州北京（现货）

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NS-102

产品介绍

NS-102 是一种选择性红藻氨酸 (GluK2) 受体拮抗剂。NS-102 是一种有效的 GluR6/7 受体拮抗剂。

生物活性

NS-102 is a selective kainate (GluK2) receptor antagonist. NS-102 is a potent GluR6/7 receptor antagonist.

体外研究

Combination of NS-102 (10 μM) and GYKI 52466 (30 μM) preventes full loss of compound action potentials (CAPs) during oxygen and glucose deprivation (OGD) and increases CAP area recovery.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

NS-102 (20, 40 or 80 μmol/litre ; in the hippocampal CA3 region) significantly reduces Sevoflurane-induced hyperactivities.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

NS-102 (20, 40 or 80 μmol/litre ; in the hippocampal CA3 region) significantly reduces Sevoflurane-induced hyperactivities.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 4 mg/mL (15.31 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.8280 mL	19.1402 mL	38.2804 mL
5 mM	0.7656 mL	3.8280 mL	7.6561 mL
10 mM	0.3828 mL	1.9140 mL	3.8280 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

参考文献

. Selva Baltan Tekkök, et al. Excitotoxic mechanisms of ischemic injury in myelinated white matter. J Cereb Blood Flow Metab. 2007 Sep;27(9):1540-52. [Content Brief]

. P Liang, et al. Sevoflurane activates hippocampal CA3 kainate receptors (Gluk2) to induce hyperactivity during induction and recovery in a mouse model. Br J Anaesth. 2017 Nov 1;119(5):1047-1054. [Content Brief]

. Barbara Gisabella, et al. Kainate receptor-mediated modulation of hippocampal fast spiking interneurons in a rat model of schizophrenia. PLoS One. 2012;7(3):e32483. [Content Brief]

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个人防护装备	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
危险品运输编码	NONH for all modes of transport

NS-102,98.23%

NS-102

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