SKF 83959 hydrobromide|cas:67287-95-0|西域试剂

SKF 83959 hydrobromide,99.86%

产品编号：Bellancom-103412| CAS NO：67287-95-0| 分子式：C₁₈H₂₁BrClNO₂| 分子量：398.72

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-103412		￥6300.00	杭州北京（现货）

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SKF 83959 hydrobromide

产品介绍

SKF83959 hydrobromide 是一种有效的选择性多巴胺 D₁-like 受体部分激动剂。 SKF83959 hydrobromide K_i 对大鼠 D₁，D₅，D₂ 和 D₃ 的值分别为 1.18, 7.56, 920 和 399 nM。SKF83959hydrobromide 是一种有效的 sigma (σ)-1 受体变构调节剂。SKF83959 hydrobromide 属于 benzazepine 家族，对认知功能障碍有改善作用。SKF83959 hydrobromide 可用于研究阿尔茨海默病和抑郁症。

生物活性

SKF83959 hydrobromide is a potent and selective dopamine D₁-like receptor partial agonist. SKF83959 hydrobromide K_i values for rat D₁, D₅, D₂ and D₃ receptors are 1.18, 7.56, 920 and 399 nM, respectively. SKF83959 hydrobromide is a potent allosteric modulator of sigma (σ)-1 receptor. SKF83959 hydrobromide belongs to benzazepine family and has improvements on cognitive dysfunction. SKF83959 hydrobromide can be used for the research of Alzheimer's disease and depression^[4].

体外研究

SKF83959 hydrobromide (10~250 μM) stimulates PIP2 hydrolysis in membranes. SKF83959 hydrobromide (0.1~10 μM; PC12 cell) changes the EC₅₀ value of SKF81297 from 0.5 nM in control tissue to 31.6 nM, 251.2 nM and 631.0 nM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

SKF83959 hydrobromide (0.5 and 1 mg/kg; i.p.; 1 hour) reverses the scopolamine-induced cognitive impairments in the passive avoidance task and Y-Maze test.
SKF83959 hydrobromide (1 mg/kg; i.p.; 30 minutes) induced memory enhancing effects are prevented by brain-derived neurotrophic factor system blockade.
SKF83959 hydrobromide has anti-amnesic activities and restores the scopolamine-decreased BDNF signaling pathway in the hippocampus in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male ICR male mice (8 weeks)
Dosage:	0.5 and 1 mg/kg
Administration:	I.p.; 1 hour
Result:	Reversed the scopolamine-induced cognitive impairments in the passive avoidance task and Y-Maze test.

Animal Model:	Male ICR male mice (8 weeks)
Dosage:	1 mg/kg
Administration:	I.p.; 30 minutes
Result:	The memory enhancing effects were prevented by BDNF system blockade.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male ICR male mice (8 weeks)
Dosage:	0.5 and 1 mg/kg
Administration:	I.p.; 1 hour
Result:	Reversed the scopolamine-induced cognitive impairments in the passive avoidance task and Y-Maze test.

Animal Model:	Male ICR male mice (8 weeks)
Dosage:	1 mg/kg
Administration:	I.p.; 30 minutes
Result:	The memory enhancing effects were prevented by BDNF system blockade.

性状

Solid

溶解性数据

In Vitro:

DMSO : 20 mg/mL (50.16 mM; Need ultrasonic and warming)

DMF : 20 mg/mL (50.16 mM; Need ultrasonic and warming)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.5080 mL	12.5401 mL	25.0803 mL
5 mM	0.5016 mL	2.5080 mL	5.0161 mL
10 mM	0.2508 mL	1.2540 mL	2.5080 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献