TAK-915|cas:1476727-50-0|西域试剂

TAK-915,99.74%

产品编号：Bellancom-103493| CAS NO：1476727-50-0| 分子式：C₁₉H₁₈F₄N₄O₅| 分子量：458.36

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-103493		￥9200.00	杭州北京（现货）
Bellancom-103493		￥14800.00	杭州北京（现货）

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TAK-915

产品介绍

TAK-915 是一种有效的，选择性的，可透过血脑屏障和口服活性的 PDE2A抑制剂，IC₅₀ 为 0.61 nM。TAK-915 对 PDE2A的选择性是 PDE1A 的 4100 倍以上。TAK-915 可用于神经精神疾病和神经退行性疾病的研究。

生物活性

TAK-915 is a potent, selective, brain-penetrant and orally active phosphodiesterase 2A (PDE2A) inhibitor with an IC₅₀ of 0.61 nM. TAK-915 is >4100-fold more selectivity for PDE2A than PDE1A. TAK-915 has the potential for neuropsychiatric and neurodegenerative disorders treatment.

体外研究

体内研究

TAK-915 (3 mg/kg; oral administration; daily; for 4 days; male F344 rats) treatment significantly reduces escape latency in aged rats in the Morris water maze task.
TAK-915 (1, 3, and 10 mg/kg, p.o.) dose-dependently attenuates the non-selective muscarinic antagonist scopolamine-induced memory deficits in rats.
Oral dosing of TAK-915 (compound 36) (3 or 10 mg/kg) in mice produces a dose-dependent increase in 3',5'-cyclic guanosine monophosphate (cGMP) levels, with significant cGMP increases observed at a dose of 10 mg/kg.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male F344 rats (10-week-old and 26-month-old) bearing morris water maze task
Dosage:	3 mg/kg
Administration:	Oral administration; daily; for 4 days
Result:	Significantly reduced escape latency in aged rats in the Morris water maze task.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male F344 rats (10-week-old and 26-month-old) bearing morris water maze task
Dosage:	3 mg/kg
Administration:	Oral administration; daily; for 4 days
Result:	Significantly reduced escape latency in aged rats in the Morris water maze task.

性状

Solid

溶解性数据

In Vitro:

DMSO : 7.5 mg/mL (16.36 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.1817 mL	10.9085 mL	21.8169 mL
5 mM	0.4363 mL	2.1817 mL	4.3634 mL
10 mM	0.2182 mL	1.0908 mL	2.1817 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式