CNQX disodium FG9065 disodium|cas:479347-85-8|西域试剂

CNQX disodium FG9065 disodium,99.73%

产品编号：Bellancom-15066A| CAS NO：479347-85-8| 分子式：C₉H₂N₄Na₂O₄| 分子量：276.12

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货号	价格	库存与货期
Bellancom-15066A	￥500.00	杭州北京（现货）
Bellancom-15066A	￥700.00	杭州北京（现货）
Bellancom-15066A	￥1400.00	杭州北京（现货）
Bellancom-15066A	￥2090.00	杭州北京（现货）
Bellancom-15066A	￥3500.00	杭州北京（现货）

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CNQX disodium FG9065 disodium

产品介绍

CNQX disodium (FG9065 disodium) 是一种有效的竞争性 AMPA /海藻酸酯受体 (AMPA/kainate receptor) 拮抗剂，IC₅₀ 分别为 0.3 μM 和 1.5 μM。CNQX disodium 是一种竞争性的非 NMDA 受体拮抗剂。CNQX disodium 会阻止大鼠恐惧增强的表达。

生物活性

CNQX disodium (FG9065 disodium) is a potent and competitive AMPA/kainate receptor antagonist with IC₅₀s of 0.3 μM and 1.5 μM, respectively. CNQX disodium is a competitive non-NMDA receptor antagonist. CNQX disodium blocks the expression of fear-potentiated startle in rats^[5].

体外研究

CNQX disodium (FG9065 disodium; 2-5 μM) reversibly blocks the Schaffer collateral and mossy fibre excitatory postsynaptic potential (EPSP), while sparing the fast and slow GABA-mediated inhibition in superfusion of hippocampal slices.
CNQX disodium (1-5 μM) produces a selective and dose-dependent reduction in the amplitude of the monosynaptic component of the DR-VRR recorded from lumbar spinal segments.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

CNQX disodium (FG9065 disodium; 0.75-3 mg/kg; IP; 20 min before testing) decreased the number of cocaine responses in a dose-dependent manner during the first 15-min cocaine-free interval^[4].
The bilateral infusion of CNQX disodium (0.5 or 1.25 μg) into the amygdala or dorsal hippocampus 10 min prior to a retention test partially blocks the expression of stepdown inhibitory avoidance in rats 24 h after training. CNQX disodium causes a complete blockade at a dose of 0.5 μg^[5].

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats weighing 180-200 g^[4]
Dosage:	0.75, 1.5, and 3 mg/kg
Administration:	IP; 20 min before testing
Result:	Decreased the number of cocaine (IV; 0.25 mg/infusion) responses in a dose-dependent manner during the first 15-min cocaine-free interval.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats weighing 180-200 g^[4]
Dosage:	0.75, 1.5, and 3 mg/kg
Administration:	IP; 20 min before testing
Result:	Decreased the number of cocaine (IV; 0.25 mg/infusion) responses in a dose-dependent manner during the first 15-min cocaine-free interval.

性状

Solid

溶解性数据

In Vitro:

DMSO : 10.53 mg/mL (38.14 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 70°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.6216 mL	18.1081 mL	36.2161 mL
5 mM	0.7243 mL	3.6216 mL	7.2432 mL
10 mM	0.3622 mL	1.8108 mL	3.6216 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献