Nelonemdaz Salfaprodil free base; Neu2000|cas:640290-67-1|西域试剂

Nelonemdaz Salfaprodil free base; Neu2000,99.61%

产品编号：Bellancom-106408| CAS NO：640290-67-1| 分子式：C₁₅H₈F₇NO₃| 分子量：383.22

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货号	价格	库存与货期
Bellancom-106408	￥800.00	杭州北京（现货）
Bellancom-106408	￥2500.00	杭州北京（现货）
Bellancom-106408	￥4500.00	杭州北京（现货）
Bellancom-106408	￥12500.00	杭州北京（现货）
Bellancom-106408	￥18500.00	杭州北京（现货）

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Nelonemdaz Salfaprodil free base; Neu2000

产品介绍

Nelonemdaz (Salfaprodil free base) 是一种 NR2B 选择性和非竞争性的 N- 甲基 -D- 天冬氨酸 (NMDA) 受体拮抗剂，也是一种自由基清除剂。Nelonemdaz 对 NMDA 和自由基诱导的细胞死亡具有出色的神经保护作用。

生物活性

Nelonemdaz (Salfaprodil free base) is an NR2B-selective and uncompetitive antagonist of N-methyl-D-aspartate (NMDA). Nelonemdaz is also a free radical scavenger. Nelonemdaz has excellent neuroprotection against NMDA- and free radical-induced cell death.

体外研究

Nelonemdaz (10-300 μM) shows apparent neuroprotection against 300 μM N-methyl-d-aspartate (NMDA) at doses as low as 30 μM.
Nelonemdazl (10-500 μM) inhibits the electrophysiologic response of cultured cortical neurons to 300 μM NMDA in a concentration-dependent manner.
Nelonemdaz (0.1-1 μM) produces a marked reduction of Fe²⁺-induced neurotoxicity, even at doses of 0.1 to 0.3 μM.
Nelonemdaz (0.1-1 μM) blocks the degeneration of neurons and glia in cortical cell cultures.
Nelonemdaz (0-350 μM) effectively scavenges superoxide radicals (IC₅₀=63.07±1.44 μM), nitric oxide (IC₅₀=155.8±4.88 μM), and hydroxyl radicals (IC₅₀=58.45±1.74 μM).
Nelonemdaz (0.78-12.5 μM) decreases the amount of antimycin A-induced ROS/RNS formation in a dose-dependent manner, with an IC₅₀ of 2.21±0.11 μM.
Nelonemdaz (0.19-12.5 μM) inhibits malondialdehyde (MDA) formation with an IC₅₀ of 2.72±0.26 μM.
Nelonemdaz (0-125 μM) effectively reduces iron-ascorbate-induced lipid peroxidation (IC₅₀=24.56±0.07 μM).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Nelonemdaz (0.5-20 mg/kg; i.v.) reduces cerebral infarct evolving 24 h after 60-mins occlusion of the middle cerebral artery occlusion (MCAO) substantially and dose dependently.
Nelonemdaz (5 mg/kg; i.v.) protects white matter such as axons and myelin as well as gray matter from ischemic brain injury.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats (260 to 300 g) (clip occlusion model)
Dosage:	0.5-20 mg/kg
Administration:	I.v. administration 5 mins after reperfusion
Result:	Produced a large neuroprotective effect, with a maximal reduction in infarct volume of 66% at doses of 2.5 to 5 mg/kg. Not observed neuronal damage in the most vulnerable cortical area after administration of 5 mg/kg.

Animal Model:	Male Sprague-Dawley rats (260 to 300 g) (intraluminal thread occlusion model)
Dosage:	5 mg/kg
Administration:	I.v. administration 30 mins after reperfusion
Result:	Did not change physiologic variables such as arterial pH, PCO₂, PO₂, and hematocrit. Reduced infarct volume evolving in the cortex and the striatum substantially. Reduced white matter damage in the striatum and external capsule markedly.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats (260 to 300 g) (clip occlusion model)
Dosage:	0.5-20 mg/kg
Administration:	I.v. administration 5 mins after reperfusion
Result:	Produced a large neuroprotective effect, with a maximal reduction in infarct volume of 66% at doses of 2.5 to 5 mg/kg. Not observed neuronal damage in the most vulnerable cortical area after administration of 5 mg/kg.

Animal Model:	Male Sprague-Dawley rats (260 to 300 g) (intraluminal thread occlusion model)
Dosage:	5 mg/kg
Administration:	I.v. administration 30 mins after reperfusion
Result:	Did not change physiologic variables such as arterial pH, PCO₂, PO₂, and hematocrit. Reduced infarct volume evolving in the cortex and the striatum substantially. Reduced white matter damage in the striatum and external capsule markedly.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 112.5 mg/mL (293.57 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.6095 mL	13.0473 mL	26.0947 mL
5 mM	0.5219 mL	2.6095 mL	5.2189 mL
10 mM	0.2609 mL	1.3047 mL	2.6095 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式