MMPIP hydrochloride|cas:1215566-78-1|西域试剂

MMPIP hydrochloride,99.03%

产品编号：Bellancom-103111| CAS NO：1215566-78-1| 分子式：C₁₉H₁₆ClN₃O₃| 分子量：369.80

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-103111	￥1600.00	杭州北京（现货）
Bellancom-103111	￥2600.00	杭州北京（现货）
Bellancom-103111	￥5300.00	杭州北京（现货）
Bellancom-103111	￥8400.00	杭州北京（现货）
Bellancom-103111	￥13500.00	杭州北京（现货）

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MMPIP hydrochloride

产品介绍

MMPIP hydrochloride 是一种变构的选择性代谢型谷氨酸受体7 (mGluR7) 拮抗剂 (K_B 值范围为 24-30 nM)。MMPIP hydrochloride 可用于研究 mGluR7 对中枢神经系统功能的作用。MMPIP hydrochloride 可减轻神经病小鼠的疼痛并使其情感和认知行为正常化。

生物活性

MMPIP hydrochloride is an allosteric metabotropic glutamate receptor 7 (mGluR7) selective antagonist (K_B values 24 -30 nM). MMPIP hydrochloride acts as a pharmacological tool for elucidating the roles of mGluR7 on central nervous system functions. MMPIP hydrochloride alleviates pain and normalizes affective and cognitive behavior in neuropathic mice.

体外研究

MMPIP inhibits L-(+)-2-amino-4-phosphonobutyric acid (L-AP4; 0.5 mM)-induced intracellular Ca²⁺ mobilization in Chinese hamster ovary (CHO) cells coexpressing rat mGluR7 with G_α15 (IC₅₀=26 nM) .
In CHO cells expressing rat mGluR7, MMPIP inhibits L-AP4-induced inhibition of forskolin-stimulated cAMP accumulation (IC₅₀ 220 nM).
MMPIP also antagonizes L-AP4-induced inhibition of cAMP accumulation with an IC₅₀ of 610 nM in CHO-human mGluR7/G_α15.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

MMPIP (10 mg/kg) attenuates the amplitude of the acoustic startle response and markedly enhances the prepulse-induced inhibition of the acoustic startle response (up to 137% of control).
MMPIP (10 mg/kg) rescues the MK-801 (0.1 mg/kg)-induced cognitive impairments, by improving the choice accuracy.
Zamifenacin exhibits short elimination half-lives (plasma 1.16 h, brain 1.75 h) following i.p. administration (10 mg/kg) in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 10 mg/mL (27.04 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7042 mL	13.5208 mL	27.0416 mL
5 mM	0.5408 mL	2.7042 mL	5.4083 mL
10 mM	0.2704 mL	1.3521 mL	2.7042 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 1 mg/mL (2.70 mM); Clear solution

此方案可获得 ≥ 1 mg/mL (2.70 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 10.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明