BIP-135|cas:941575-71-9|西域试剂

BIP-135,99.86%

产品编号：Bellancom-111055| CAS NO：941575-71-9| 分子式：C₂₁H₁₃BrN₂O₃| 分子量：421.24

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货号	价格	库存与货期
Bellancom-111055	￥1500.00	杭州北京（现货）
Bellancom-111055	￥2400.00	杭州北京（现货）
Bellancom-111055	￥4700.00	杭州北京（现货）
Bellancom-111055	￥7500.00	杭州北京（现货）
Bellancom-111055	￥11800.00	杭州北京（现货）

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BIP-135

产品介绍

BIP-135 是一个高效、选择性的，ATP 竞争性的 GSK-3 抑制剂，对 GSK-3α 和 GSK-3β 作用的IC₅₀ 值分别为 16 nM 和 21 nM。BIP 135 具有神经保护作用。

生物活性

BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor, with IC₅₀s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect.

体外研究

BIP-135 (20-30 μM; 72 hours) increases the survival motor neuron (SMN) protein levels at a dose of 25 μM in human SMA fibroblasts. And the typical bell-shaped dose-response curve is observed due to some toxicity at higher concentrations.
BIP-135 (20 μM; 48 hours) is a superior neuroprotective agent in the model of oxidative stress.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	Human SMA fibroblasts
Concentration:	20 μM, 25 μM, 30 μM
Incubation Time:	72 hours
Result:	Led to a 7-fold increase in SMN levels at 25 μM.

体内研究
(In Vivo)

BIP-135 does not appear to be toxic and was well-tolerated by the animals (no decrease in body weight).
BIP-135 (75 mg/kg; i.p.; daily; from postnatal day 0 to 21) prolongs the median survival time of Δ7 SMA KO mouse model of spinal muscular atrophy.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male and female SMN2^+/+, SMN2Δ7^+/+, Smn^+/– mice
Dosage:	75 mg/kg
Administration:	Intraperitoneal injection; daily; from postnatal day 0 to 21
Result:	Caused a modest extension in the median survival of SMA KO animals by two days.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male and female SMN2^+/+, SMN2Δ7^+/+, Smn^+/– mice
Dosage:	75 mg/kg
Administration:	Intraperitoneal injection; daily; from postnatal day 0 to 21
Result:	Caused a modest extension in the median survival of SMA KO animals by two days.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male and female SMN2^+/+, SMN2Δ7^+/+, Smn^+/– mice
Dosage:	75 mg/kg
Administration:	Intraperitoneal injection; daily; from postnatal day 0 to 21
Result:	Caused a modest extension in the median survival of SMA KO animals by two days.

性状

Solid

溶解性数据

In Vitro:

DMSO : 62.5 mg/mL (148.37 mM; ultrasonic and warming and heat to 70°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3739 mL	11.8697 mL	23.7394 mL
5 mM	0.4748 mL	2.3739 mL	4.7479 mL
10 mM	0.2374 mL	1.1870 mL	2.3739 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式