TCB2|cas:912342-28-0|西域试剂

TCB2,99.21%

产品编号：Bellancom-103102| CAS NO：912342-28-0| 分子式：C₁₁H₁₅Br₂NO₂| 分子量：353.05

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货号	价格	库存与货期
Bellancom-103102	￥2500.00	杭州北京（现货）
Bellancom-103102	￥3800.00	杭州北京（现货）
Bellancom-103102	￥7500.00	杭州北京（现货）
Bellancom-103102	￥12000.00	杭州北京（现货）

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TCB2

产品介绍

TCB2 是 5-羟色胺 2A 受体 (5-HT_2A) 的激动剂.

生物活性

TCB2 is an agonist of serotonin 5-HT_2A receptor.

体外研究

The selective 5-HT_2A agonist TCB2 at 30 nM produces a marked shift to the right in the competition curve obtained with the 5-HT_1A receptor agonist ipsapirone from [³H]-8-OHDPAT binding sites in both areas of the brain. A significant increase in the mean K_i value is obtained with TCB2, demonstrating a reduction in the affinity of the high-affinity 5-HT_1A agonist binding sites by the 5-HT_2A agonist in both regions. In the case of hippocampus, there are also indications for antagonistic effects of ketanserin.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

In an initial dose-response study, TCB2 (0.5, 1.0, and 2.5 mg/kg) and DOI (0.5, 1.0, 2.5, and 5.0 mg/kg) induce head twitches in C57BL/6J mice in a dose-dependent manner compared to vehicle. Head twitches induced by TCB2 and DOI are similar across the doses, with the exception that at the highest dose (5.0 mg/kg), TCB2 induces half as many head twitches as does DOI (p=0.021). Confirming 5-HT2A mediation of the head twitch response, in two separate studies, pretreatment with the selective 5-HT_2A antagonist MDL 11,939 (1.0 mg/kg) block head twitches induced by DOI (2.5 mg/kg) and by TCB2 (2.5 mg/kg; p<0.0001). Compared to vehicle, corticosterone levels are increased following TCB2 (5.0 mg/kg, p=0.01; 10.0, p=0.012; with a trend following 2.5 mg/kg, p=0.079) and DOI (10.0 mg/kg, p=0.035).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (283.25 mM; ultrasonic and warming and heat to 60°C)

H₂O : 25 mg/mL (70.81 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.8325 mL	14.1623 mL	28.3246 mL
5 mM	0.5665 mL	2.8325 mL	5.6649 mL
10 mM	0.2832 mL	1.4162 mL	2.8325 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献