Ecopipam hydrobromide SCH 39166 hydrobromide,99.0%
产品编号:Bellancom-110033| CAS NO:2587360-22-1| 分子式:C19H21BrClNO| 分子量:394.73
本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用,
Ecopipam hydrobromide SCH 39166 hydrobromide
产品介绍 | Ecopipam (SCH 39166) hydrobromide 是一种有效的、选择性、具有口服活性的多巴胺 D1/D5 受体拮抗剂,Ki 值分别为 1.2 nM 和 2.0 nM。Ecopipam hydrobromide 对 D2、D4、5-HT 和 α2a 受体 (Ki=0.98,5.52,0.08 和 0.73 μM) 显示出超过 40 倍的选择性。Ecopipam hydrobromide 可用于精神分裂症和肥胖症的研究。 | ||||||||
---|---|---|---|---|---|---|---|---|---|
生物活性 | Ecopipam (SCH 39166) hydrobromide is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam hydrobromide shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam hydrobromide can be used for the research of schizophrenia and obesity. | ||||||||
体外研究 |
Ecopipam (2 μM) hydrobromide 完全消除多巴胺 (10 μM) 在孤立的皮质海马结构中的促惊厥作用。 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||
体内研究 |
Ecopipam hydrobromide (10,mg/kg,口服) 拮抗大鼠中 Apomorphine 诱导的刻板印象[4]。 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
| ||||||||
体内研究 |
Ecopipam hydrobromide (10,mg/kg,口服) 拮抗大鼠中 Apomorphine 诱导的刻板印象[4]。 西域 has not independently confirmed the accuracy of these methods. They are for reference only.
| ||||||||
性状 | Solid | ||||||||
溶解性数据 | |||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 |
-20°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) | ||||||||
参考文献 |
|