Ecopipam hydrobromide SCH 39166 hydrobromide,99.0%

产品编号:Bellancom-110033| CAS NO:2587360-22-1| 分子式:C19H21BrClNO| 分子量:394.73

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Bellancom-110033
4500.00 杭州 北京(现货)

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Ecopipam hydrobromide SCH 39166 hydrobromide

产品介绍 Ecopipam (SCH 39166) hydrobromide 是一种有效的、选择性、具有口服活性的多巴胺 D1/D5 受体拮抗剂,Ki 值分别为 1.2 nM 和 2.0 nM。Ecopipam hydrobromide 对 D2、D4、5-HT 和 α2a 受体 (Ki=0.98,5.52,0.08 和 0.73 μM) 显示出超过 40 倍的选择性。Ecopipam hydrobromide 可用于精神分裂症和肥胖症的研究。
生物活性

Ecopipam (SCH 39166) hydrobromide is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam hydrobromide shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam hydrobromide can be used for the research of schizophrenia and obesity.

体外研究

Ecopipam (2 μM) hydrobromide 完全消除多巴胺 (10 μM) 在孤立的皮质海马结构中的促惊厥作用

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Ecopipam hydrobromide (10,mg/kg,口服) 拮抗大鼠中 Apomorphine 诱导的刻板印象[4]
Ecopipam hydrobromide (5 和 10 μM,灌注,1 μL/分钟) 可逆地和剂量依赖性地减少大鼠纹状体中乙酰胆碱的释放[5]

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male young adult Long-Evans rats were injected with Nicotine
Dosage: 0.003, 0.01, 0.03, 0.1, 0.3 mg/kg
Administration: A single s.c. 20 min before Nicotine (0.1 mg/kg)
Result: Dose-dependently reduced pressing on both active and inactive levers.
体内研究

Ecopipam hydrobromide (10,mg/kg,口服) 拮抗大鼠中 Apomorphine 诱导的刻板印象[4]
Ecopipam hydrobromide (5 和 10 μM,灌注,1 μL/分钟) 可逆地和剂量依赖性地减少大鼠纹状体中乙酰胆碱的释放[5]

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male young adult Long-Evans rats were injected with Nicotine
Dosage: 0.003, 0.01, 0.03, 0.1, 0.3 mg/kg
Administration: A single s.c. 20 min before Nicotine (0.1 mg/kg)
Result: Dose-dependently reduced pressing on both active and inactive levers.
性状Solid
溶解性数据
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献

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