Thiethylperazine|cas:1420-55-9|西域试剂

Thiethylperazine,99.41%

产品编号：Bellancom-B1794| CAS NO：1420-55-9| 分子式：C₂₂H₂₉N₃S₂| 分子量：399.62

噻乙基拉嗪是吩噻嗪衍生物，是一种口服有效的多巴胺D2受体和组胺H1受体拮抗剂。Thiethylprazine也是一种选择性ABCC1活化剂，可降低小鼠的淀粉样β（aβ）负荷。噻乙基拉嗪具有止吐、抗精神病和抗菌作用。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-B1794	￥1000.00	杭州北京（现货）
Bellancom-B1794	￥1500.00	杭州北京（现货）
Bellancom-B1794	￥4500.00	杭州北京（现货）
Bellancom-B1794	￥6900.00	杭州北京（现货）

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Thiethylperazine

产品介绍

Thiethylperazine 是一种吩噻嗪衍生物，是一种口服有效的多巴胺 D2 受体和组胺 H1 受体拮抗剂。Thiethylperazine 也是一种选择性的 ABCC1 激活剂，可减少小鼠中的淀粉样 β (Aβ) 负荷。Thiethylperazine 具有止吐，抗精神病和抗菌作用。

生物活性

Thiethylperazine, a phenothiazine derivate, is an orally active and potent dopamine D2-receptor and histamine H1-receptor antagonist. Thiethylperazine is also a selective ABCC1activator that reduces amyloid-β (Aβ) load in mice. Thiethylperazine has anti-emetic, antipsychotic and antimicrobial effects.

体外研究

Thiethylperazine can enhance the antibiotic (Vancomycin) activity at a concentration as low as 2 μg/mL. Thiethylperazine inhibits Vancomycin-sensitive E. faecalis ATCC 29212, Vancomycin-resistant E. faecalis ATCC 51299 and vancomycin-resistant E. faecalis (VREF) isolates with MIC values of 8 μg/mL, 16 μg/mL and 8 μg/mL, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Thiethylperazine (3 mg/kg; intramuscular injection; twice daily; for 30 days) significantly reduces Aβ42 levels in young APP/PS1 mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Young Aβ precursor protein (APPswe) and mutant presenilin-1 (PS1) (APP/PS1) mice
Dosage:	3 mg/kg
Administration:	Intramuscular injection; twice daily; for 30 days
Result:	Significantly reduced Aβ42 levels in APP/PS1 mice.

体内研究

Thiethylperazine (3 mg/kg; intramuscular injection; twice daily; for 30 days) significantly reduces Aβ42 levels in young APP/PS1 mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Young Aβ precursor protein (APPswe) and mutant presenilin-1 (PS1) (APP/PS1) mice
Dosage:	3 mg/kg
Administration:	Intramuscular injection; twice daily; for 30 days
Result:	Significantly reduced Aβ42 levels in APP/PS1 mice.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (250.24 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.5024 mL	12.5119 mL	25.0238 mL
5 mM	0.5005 mL	2.5024 mL	5.0048 mL
10 mM	0.2502 mL	1.2512 mL	2.5024 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献

. Czeizel AE, et al. Case-control study of teratogenic potential of thiethylperazine, an anti-emetic drug. BJOG. 2003 May;110(5):497-9. [Content Brief]

. Krohn M, et al. Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice. J Clin Invest. 2011 Oct;121(10):3924-31. [Content Brief]

. Rahbar M, et al. Enhancement of vancomycin activity by phenothiazines against vancomycin-resistant Enterococcus faecium in vitro. Basic Clin Pharmacol Toxicol. 2010 Aug;107(2):676-9. [Content Brief]

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Thiethylperazine,99.41%

Thiethylperazine

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