RO 4938581|cas:883093-10-5|西域试剂

RO 4938581,99.30%

产品编号：Bellancom-107489| CAS NO：883093-10-5| 分子式：C₁₃H₈BrF₂N₅| 分子量：352.14

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货号	价格	库存与货期
Bellancom-107489	￥3500.00	杭州北京（现货）
Bellancom-107489	￥6000.00	杭州北京（现货）
Bellancom-107489	￥12500.00	杭州北京（现货）

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RO 4938581

产品介绍

RO 4938581 是一种有效的，选择性的 GABA_A α5 反向激动剂，对 GABA_A α5β3γ2a 的 K_i 值为 4.6 nM，对 α1β3γ2a，α2β3γ2a，α3β3γ2a 的亲和性相对较低，K_i 值分别为 174，185 和 80 nM；RO 4938581 可用于认知功能障碍的研究。

生物活性

RO 4938581 is a potent and selective GABA_A α5 inverse agonist, with a K_i of 4.6 nM for GABA_A α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (K_i, 174, 185, 80 nM, respectively); RO 4938581 is used in the research of cognitive dysfunction.

体外研究

RO 4938581 is a potent and selective GABA_A α5 inverse agonist, with a K_i of 4.6 nM for GABA_A α5β3γ2a, and shows a lower affinity at α1β3γ2a, α2β3γ2a, α3β3γ2a (K_i, 174, 185, 80 nM, respectively).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

RO 4938581 (0.3-1 mg/kg, p.o.) reverses a working memory impairment induced by scopolamine the delayed match to position (DMTP) task and a spatial learning impairment induced by diazepam (RO 4938581; 1-10 mg/kg, po).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (283.98 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.8398 mL	14.1989 mL	28.3978 mL
5 mM	0.5680 mL	2.8398 mL	5.6796 mL
10 mM	0.2840 mL	1.4199 mL	2.8398 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式