NMDAR/TRPM4-IN-2 free base|cas:1353979-43-7|西域试剂

NMDAR/TRPM4-IN-2 free base,99.24%

产品编号：Bellancom-139192A| CAS NO：1353979-43-7| 分子式：C₁₁H₁₇BrN₂| 分子量：257.17

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货号	价格	库存与货期
Bellancom-139192A	￥500.00	杭州北京（现货）
Bellancom-139192A	￥750.00	杭州北京（现货）
Bellancom-139192A	￥2300.00	杭州北京（现货）
Bellancom-139192A	￥3680.00	杭州北京（现货）

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NMDAR/TRPM4-IN-2 free base

产品介绍

NMDAR/TRPM4-IN-2 free base (化合物 8) 是一种有效的 NMDAR/TRPM4 相互作用界面抑制剂。NMDAR/TRPM4-IN-2 free base 具有神经保护活性。NMDAR/TRPM4-IN-2 free base 可预防 NMDA 诱导的海马神经元细胞死亡和线粒体功能障碍，其 IC₅₀ 值为 2.1 μM。NMDAR/TRPM4-IN-2 free base 保护小鼠免受 MCAO 诱导的脑损伤和 NMDA 诱导的视网膜神经节细胞丢失。

生物活性

NMDAR/TRPM4-IN-2 free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. NMDAR/TRPM4-IN-2 free base shows neuroprotective activity. NMDAR/TRPM4-IN-2 free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC₅₀ of 2.1 μM. NMDAR/TRPM4-IN-2 free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss.

体外研究

NMDAR/TRPM4-IN-2 free base (compound 8) (0-10 μM) reduces the interactions of GluN2A and GluN2B with TRPM4 in a dose-dependent manner.
NMDAR/TRPM4-IN-2 free base eliminates the CREB shutoff pathway and restores ERK1/2 activation and IEG induction while sparing the synaptic activity-driven, transcription-promoting activities of NMDARs.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Liquid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (388.85 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.8885 mL	19.4424 mL	38.8848 mL
5 mM	0.7777 mL	3.8885 mL	7.7770 mL
10 mM	0.3888 mL	1.9442 mL	3.8885 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式