AR-C102222 hydrochloride|cas:1781934-50-6|西域试剂

AR-C102222 hydrochloride,98.80%

产品编号：Bellancom-12122A| CAS NO：1781934-50-6| 分子式：C₁₉H₁₇ClF₂N₆O| 分子量：418.83

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货号	价格	库存与货期
Bellancom-12122A	￥1900.00	杭州北京（现货）
Bellancom-12122A	￥5750.00	杭州北京（现货）
Bellancom-12122A	￥9800.00	杭州北京（现货）

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AR-C102222 hydrochloride

产品介绍

AR-C102222 hydrochloride 是一种有效的、竞争性的、有口服活性的、高度选择性的诱导型一氧化氮合酶 (iNOS) 抑制剂，IC₅₀ 值为 37 nM。AR-C102222 hydrochloride 具有抗伤害和抗炎活性。

生物活性

AR-C102222 hydrochloride is a potent, competitive, orally active and highly selective inducible nitric oxide synthase (iNOS) inhibitor, with an IC₅₀ of 37 nM. AR-C102222 hydrochloride has antinociception and anti-inflammatory activities.

体外研究

体内研究

AR-C102222 (3, 10, 30, 100 mg/kg, P.O.) attenuates arachidonic acid-induced ear inflammation and possesses anti-inflammatory activity.
AR-C102222 shows good efficacy in a rat adjuvant-induced arthritis model.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Balb/c mice (20-25 g).
Dosage:	3, 10, 30, 100 mg/kg.
Administration:	P.O. 55 min before the administration of 0.6% acetic acid (i.p., 1 mL/100 g volume).
Result:	Significantly inhibited arachidonic acid-induced ear inflammation following a dose of 100 mg/kg of has a maximal inhibition of approximately 79%.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Balb/c mice (20-25 g).
Dosage:	3, 10, 30, 100 mg/kg.
Administration:	P.O. 55 min before the administration of 0.6% acetic acid (i.p., 1 mL/100 g volume).
Result:	Significantly inhibited arachidonic acid-induced ear inflammation following a dose of 100 mg/kg of has a maximal inhibition of approximately 79%.