N-Acetyl lysyltyrosylcysteine amide|cas:1287585-40-3|西域试剂

N-Acetyl lysyltyrosylcysteine amide

产品编号：Bellancom-125039| CAS NO：1287585-40-3| 分子式：C₂₀H₃₁N₅O₅S| 分子量：453.56

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货号	价格	库存与货期
Bellancom-125039	￥900.00	杭州北京（现货）
Bellancom-125039	￥2250.00	杭州北京（现货）
Bellancom-125039	￥3800.00	杭州北京（现货）

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N-Acetyl lysyltyrosylcysteine amide

产品介绍

N-Acetyl lysyltyrosylcysteine amide 是一种有效的，可逆的，特异性且无毒的髓过氧化物酶 (MPO) 三肽抑制剂。N-Acetyl lysyltyrosylcysteine amide 在体内可有效抑制 MPO 产生有毒氧化剂。N-Acetyl lysyltyrosylcysteine amide 减轻中风后大脑的神经元损伤，并保留脑组织和神经功能。N-Acetyl lysyltyrosylcysteine amide 抑制MPO依赖性次氯酸 (HOCl) 的生成，蛋白质硝化和 LDL 氧化。

生物活性

N-Acetyl lysyltyrosylcysteine amide is a potent, reversible, specific, and non-toxic tripeptide inhibitor of myeloperoxidase (MPO). N-Acetyl lysyltyrosylcysteine amide effectively inhibits MPO generation of toxic oxidants in vivo. N-Acetyl lysyltyrosylcysteine amide reduces neuronal damage and preserves brain tissue and neurological function in the stroked brain. N-Acetyl lysyltyrosylcysteine amide inhibits MPO-dependent hypochlorous acid (HOCl) generation, protein nitration, and LDL oxidation.

体外研究

体内研究

N-Acetyl lysyltyrosylcysteine amide (KYC) significantly decreases infarct size, blood-brain barrier leakage, infiltration of myeloid cells, loss of neurons, and apoptosis in the brains of middle cerebral artery occlusion (MCAO) mice.
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 3-7 days) significantly reduces neurological severity scores and infarct size in MCAO mice.
N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily 7 days) significantly protects BBB function and decreased neutrophil infiltration. N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily 7 days) significantly reduces microglia/macrophage activation and neuron loss in MCAO mice. N-Acetyl lysyltyrosylcysteine amide (10 mg/kg; i.p.; daily for 3-7 days) decreases apoptosis and cell injury in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduced MPO in the brains of MCAO mice. N-Acetyl lysyltyrosylcysteine amide reduces NO2Tyr and 4-HNE in MCAO mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	8-10 weeks old C57BL/6J mice (middle cerebral artery occlusion (MCAO) mode)
Dosage:	10 mg/kg
Administration:	I.p.; daily for 3-7 days
Result:	Significantly reduced neurological deficit and brain infarct size in mice subjected to MCAO.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	8-10 weeks old C57BL/6J mice (middle cerebral artery occlusion (MCAO) mode)
Dosage:	10 mg/kg
Administration:	I.p.; daily for 3-7 days
Result:	Significantly reduced neurological deficit and brain infarct size in mice subjected to MCAO.

性状

Solid

溶解性数据

In Vitro:

H₂O : 62.5 mg/mL (137.80 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.2048 mL	11.0239 mL	22.0478 mL
5 mM	0.4410 mL	2.2048 mL	4.4096 mL
10 mM	0.2205 mL	1.1024 mL	2.2048 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

参考文献