SAE-14 GPR183 antagonist-1|cas:1241280-25-0|西域试剂

SAE-14 GPR183 antagonist-1,98.26%

产品编号：Bellancom-147222| CAS NO：1241280-25-0| 分子式：C₁₉H₁₉F₃N₂O₂| 分子量：364.36

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货号	价格	库存与货期
Bellancom-147222	￥3000.00	杭州北京（现货）
Bellancom-147222	￥4300.00	杭州北京（现货）
Bellancom-147222	￥8100.00	杭州北京（现货）
Bellancom-147222	￥12000.00	杭州北京（现货）

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SAE-14 GPR183 antagonist-1

产品介绍

SAE-14 (compound SAE-14) 是一种有效、特异的 GPR183 拮抗剂，IC₅₀值为 28.5 nM，可抑制 HL-60 细胞中 7α, 25-OHC 诱导的钙信号转导， IC₅₀ 值低于 50 nM。SAE-14 可逆转小鼠的异位性疼痛。

生物活性

SAE-14 (compound SAE-14) is a potent, specific GPR183 antagonist with an IC₅₀ value of 28.5 nM, can antagonize 7α, 25-OHC–induced calcium mobilization with IC₅₀ value below 50 nM in HL-60 cells. GPR183 antagonist-1 can reverse allodynia in mice.

体外研究

SAE-14 (compound SAE-14) can able to antagonize 7α, 25-OHC–induced calcium mobilization with an IC₅₀ value below 50 nM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	The human leukemia (HL)-60 cells
Concentration:	5×of the antagonist
Incubation Time:	15 min
Result:	Had GPR183-specific (IC₅₀: 28.5nM) and abolished 7a, 25-OHC–induced calcium mobilization in the HL-60 cells.

体内研究
(In Vivo)

SAE-14 (compound SAE-14) (i.th.; 2.9 µM; once) can reverse nerve injury-induced allodynia in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male and female ICR mice
Dosage:	2.9 µM
Administration:	intrathecal (i.th.) injections; 2.9 µM; once
Result:	Reversed CCI-induced mechanical allodynia in a time-dependent manner.

体内研究

SAE-14 (compound SAE-14) (i.th.; 2.9 µM; once) can reverse nerve injury-induced allodynia in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male and female ICR mice
Dosage:	2.9 µM
Administration:	intrathecal (i.th.) injections; 2.9 µM; once
Result:	Reversed CCI-induced mechanical allodynia in a time-dependent manner.

体内研究

SAE-14 (compound SAE-14) (i.th.; 2.9 µM; once) can reverse nerve injury-induced allodynia in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male and female ICR mice
Dosage:	2.9 µM
Administration:	intrathecal (i.th.) injections; 2.9 µM; once
Result:	Reversed CCI-induced mechanical allodynia in a time-dependent manner.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (274.45 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7445 mL	13.7227 mL	27.4454 mL
5 mM	0.5489 mL	2.7445 mL	5.4891 mL
10 mM	0.2745 mL	1.3723 mL	2.7445 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式