Small Cardioactive Peptide B (SCPB)|cas:84746-43-0|西域试剂

Small Cardioactive Peptide B (SCPB),98.10%

产品编号：Bellancom-P1495| CAS NO：84746-43-0| 分子式：C₅₂H₈₀N₁₄O₁₁S₂| 分子量：1141.41

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货号	价格	库存与货期
Bellancom-P1495	￥700.00	杭州北京（现货）
Bellancom-P1495	￥2100.00	杭州北京（现货）
Bellancom-P1495	￥3300.00	杭州北京（现货）

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Small Cardioactive Peptide B (SCPB)

产品介绍

Small Cardioactive Peptide B (SCP_B) 是一种神经活性肽，刺激心脏和鳃组织的颗粒组分中的腺苷酸环化酶 (adenylate cyclase) 活性，EC₅₀ 分别为 0.1 和 1.0 μM。

生物活性

Small Cardioactive Peptide B (SCP_B), a neurally active peptide, stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with EC₅₀s of 0.1 and 1.0 μM, respectively.

体外研究

Small cardioactive peptide B (SCP_B) is a neurally active peptide endogenous to Aplysia. Small cardioactive peptide B (SCP_B) possesses cardioexcitatory effects in Aplysia and reported a threshold concentration of 0.01 nM for both native and synthetic Small cardioactive peptide B (SCP_B) stimulated effects on the isolated heart. Effects of Small Cardioactive Peptide B (SCP_B) on the physiology of the isolated heart and gill preparations from the mollusc Aplysia californica were examined. In addition, the effects of Small Cardioactive Peptide B (SCP_B) and FMRFamide (Phe-Met-Arg-Phe-NH2) on adenylate cyclase activity are compared in particulate fractions of heart and gill tissues, respectively. Small Cardioactive Peptide B (SCP_B) is found to exert dose-dependent, reversible changes in cardiac activity when perfused through the isolated heart. The EC₅₀ values effecting changes in heart rate and force of contraction are 0.03 and 0.3 nM, respectively; minimum concentrations find to effect changes in heart rate and force of contraction are normally 0.001 and 1 pM, respectively. When perfused through the isolated gill, Small Cardioactive Peptide B (SCP_B) is found to suppress the gill withdrawal response amplitude with a threshold concentration of 0.01 pM and an EC₅₀ value of 0.03 nM. Suppression of the gill withdrawal response amplitude by Small Cardioactive Peptide B (SCP_B)is found to be dose dependent and reversible up to a concentration of 1nM. At higher concentrations, the suppression tended to persist irreversibly. Small Cardioactive Peptide B (SCP_B) stimulates adenylate cyclase activity in particulate fractions of both heart and gill tissues with an EC₅₀ of 0.1 and 1.0μM, respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

H₂O : 50 mg/mL (43.81 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.8761 mL	4.3805 mL	8.7611 mL
5 mM	0.1752 mL	0.8761 mL	1.7522 mL
10 mM	0.0876 mL	0.4381 mL	0.8761 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light, under nitrogen