Fosnetupitant Pronetupitant|cas:1703748-89-3|西域试剂

Fosnetupitant Pronetupitant,95.0%

产品编号：Bellancom-17615| CAS NO：1703748-89-3| 分子式：C₃₁H₃₅F₆N₄O₅P| 分子量：688.60

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-17615		￥4600.00	杭州北京（现货）

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Fosnetupitant Pronetupitant

产品介绍

Fosnetupitant (Pronetupitant) 是 Netupitant 的亚甲基磷酸前体活性分子。Fosnetupitant (Pronetupitant) 对人 NK₁ 受体的 pK_i 值为 9.5。

生物活性

Fosnetupitant (Pronetupitant) a methylene phosphate proagent of Netupitant. Fosnetupitant (Pronetupitant) exhibits a pK_i of 9.5 for human NK₁ receptor.

体外研究

Fosnetupitant (Pronetupitant) displays micromolar affinity for the 5-HT6 (pK_i ∼ 5.2) receptor and type L Ca²⁺ channels (pK_i ∼ 5.7) and does not bind all the other proteins investigated.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Pronetupitant is rapidly and extensively converted to Netupitant after i.v. injection in rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Pronetupitant is rapidly and extensively converted to Netupitant after i.v. injection in rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (145.22 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.4522 mL	7.2611 mL	14.5222 mL
5 mM	0.2904 mL	1.4522 mL	2.9044 mL
10 mM	0.1452 mL	0.7261 mL	1.4522 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

参考文献