Nav1.7-IN-3|cas:1788872-06-9|西域试剂

Nav1.7-IN-3,98.43%

产品编号：Bellancom-101789| CAS NO：1788872-06-9| 分子式：C₁₇H₂₀ClFN₄O₂S₂| 分子量：430.95

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-101789	￥4000.00	杭州北京（现货）
Bellancom-101789	￥6800.00	杭州北京（现货）
Bellancom-101789	￥13500.00	杭州北京（现货）

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Nav1.7-IN-3

产品介绍

Nav1.7-IN-3是选择性，有口服活性的电压门控钠离子通道 Nav1.7 抑制剂，IC₅₀ 为8 nM。CNS渗透能力有限。缓解疼痛。

生物活性

Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC₅₀ of 8 nM. Pain relief. Limited CNS penetration.

体外研究

体内研究

Nav1.7-IN-3 (compound 5) shows excellent potency, selectivity, behavioral efficacy in a rodent pain model (30 mg/kg, oral, 35 minutes), and efficacy in a mouse itch model (30 mg/kg, oral, 30 minutes).

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 male mice (n=8/group, 25-30g)
Dosage:	1, 3, and 10 mg/kg
Administration:	Oral (0-35 mintues)
Result:	Nav1.7-IN-3 demonstrates statistically significant, dose-dependent reversal of these effects in the acute phase of the experiment (0-5 min period post formalin injection) and the tonic phase of the experiment (20-35 min period post formalin injection) with full reversal of formalin effects in the tonic phase

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 male mice (n=8/group, 25-30g)
Dosage:	1, 3, and 10 mg/kg
Administration:	Oral (0-35 mintues)
Result:	Nav1.7-IN-3 demonstrates statistically significant, dose-dependent reversal of these effects in the acute phase of the experiment (0-5 min period post formalin injection) and the tonic phase of the experiment (20-35 min period post formalin injection) with full reversal of formalin effects in the tonic phase