Dazucorilant CORT113176|cas:1496508-34-9|西域试剂

Dazucorilant CORT113176,98.91%

产品编号：Bellancom-132811| CAS NO：1496508-34-9| 分子式：C₂₉H₂₂F₄N₄O₃S| 分子量：582.57

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-132811		￥8100.00	杭州北京（现货）
Bellancom-132811		￥13000.00	杭州北京（现货）

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Dazucorilant CORT113176

产品介绍

Dazucorilant (CORT113176) 是一种非甾体糖皮质激素受体 (GR) 调节剂，在体外其 K_i 值 <1 nM。Dazucorilant 可用于神经系统疾病的研究。

生物活性

Dazucorilant (CORT113176) is a selective and high affinity non-steroidal glucocorticoid receptor (GR) modulator with a K_i value ＜1 nM in vitro. Dazucorilant can be used for the research of neurological disorders.

体外研究

In HepG2 human cells or in human hepatocytes, Dazucorilant acts as full antagonist since it is able to prevent the dexamethasone-induced increase in TAT activity and to induce non-measurable agonist activity in the absence of dexamethasone.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Dazucorilant (30 mg/kg/day; s.c.) makes mice show reversed abnormalities of motoneurons and down-regulated proinflammatory mediators and glial reactivity.
Dazucorilant (5, 10 or 20 mg/kg; i.p.) reverses hippocampal amyloid-β peptide generation, neuroinflammation and apoptotic processes, restores the hippocampal levels of synaptic markers, reestablishes basal plasma levels of glucocorticoids and improves cognitive function at a dose of 10 mg/kg.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Wobbler mice (five-month-old)
Dosage:	30 mg/kg/day
Administration:	S.c.
Result:	Wobbler mice showed reversed abnormalities of motoneurons and down-regulated proinflammatory mediators and glial reactivity.

Animal Model:	Adult SD male rats
Dosage:	5, 10 or 20 mg/kg
Administration:	I.p.
Result:	Reversed hippocampal amyloid-β peptide generation, neuroinflammation and apoptotic processes, restored the hippocampal levels of synaptic markers, reestablished basal plasma levels of glucocorticoids and improved cognitive function at a dose of 10 mg/kg.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Wobbler mice (five-month-old)
Dosage:	30 mg/kg/day
Administration:	S.c.
Result:	Wobbler mice showed reversed abnormalities of motoneurons and down-regulated proinflammatory mediators and glial reactivity.

Animal Model:	Adult SD male rats
Dosage:	5, 10 or 20 mg/kg
Administration:	I.p.
Result:	Reversed hippocampal amyloid-β peptide generation, neuroinflammation and apoptotic processes, restored the hippocampal levels of synaptic markers, reestablished basal plasma levels of glucocorticoids and improved cognitive function at a dose of 10 mg/kg.