SUVN-911|cas:2414674-71-6|西域试剂

SUVN-911,99.40%

产品编号：Bellancom-136146| CAS NO：2414674-71-6| 分子式：C₁₁H₁₄Cl₂N₂O| 分子量：261.15

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货号	价格	库存与货期
Bellancom-136146	￥3500.00	杭州北京（现货）
Bellancom-136146	￥5800.00	杭州北京（现货）
Bellancom-136146	￥16500.00	杭州北京（现货）
Bellancom-136146	￥25500.00	杭州北京（现货）

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SUVN-911

产品介绍

SUVN-911 是一种高效、选择性的，有大脑通透性和口服生物活性的神经元烟碱乙酰胆碱 α4β2 受体 (α4β2 receptor) 拮抗剂，K_i 值为 1.5 nM。SUVN-911 具有抗抑郁作用。

生物活性

SUVN-911 is a potent, selective, brain penetrated and orally bioavailable neuronal nicotinic acetylcholine α4β2 receptor antagonist, with a K_i of 1.5 nM. SUVN-911 has antidepressant activity.

体外研究

SUVN-911 displays high selectivity for α4β2 over α3β4 nAChR.
SUVN-911 shows good selectivity against over 70 receptors which includes GPCRs, ion channels, enzymes, peptides, steroids, second messengers, growth factors and prostaglandins.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

SUVN-911 is devoid of cardiovascular and gastrointestinal side effects.
SUVN-911 (1.0-10.0 mg/kg; p.o.; daily; for 3 days) shows significant antidepressant effects.
SUVN-911 shows metabolic stability in rats.
SUVN-911 (3 mg/kg; p.o.) has shown high oral exposures, longer half-lives and adequate brain penetration in Wistar rats.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (180-230 g)
Dosage:	1 mg/kg, 3 mg/kg, 10.0 mg/kg
Administration:	Oral administration, daily, for 3 days
Result:	Showed antidepressant like activity with no signs of tachyphylaxis.

Animal Model:	Male Wistar rats (225 ± 25 g)
Dosage:	3 mg/kg (Pharmacokinetic Analysis)
Administration:	Oral administration
Result:	AUC=3507 ng*h/mL, T_1/2=3.34 hours.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Wistar rats (180-230 g)
Dosage:	1 mg/kg, 3 mg/kg, 10.0 mg/kg
Administration:	Oral administration, daily, for 3 days
Result:	Showed antidepressant like activity with no signs of tachyphylaxis.

Animal Model:	Male Wistar rats (225 ± 25 g)
Dosage:	3 mg/kg (Pharmacokinetic Analysis)
Administration:	Oral administration
Result:	AUC=3507 ng*h/mL, T_1/2=3.34 hours.

性状

Solid

溶解性数据

In Vitro:

DMSO : 125 mg/mL (478.65 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.8292 mL	19.1461 mL	38.2922 mL
5 mM	0.7658 mL	3.8292 mL	7.6584 mL
10 mM	0.3829 mL	1.9146 mL	3.8292 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献