(R,R)-BD-AcAc 2 酮酯; (R,R-Ketone Ester)|cas:1208313-97-6|西域试剂

(R,R)-BD-AcAc 2 酮酯; (R,R-Ketone Ester),95.10%

产品编号：Bellancom-15344| CAS NO：1208313-97-6| 分子式：C₈H₁₆O₄| 分子量：176.21

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-15344		￥7500.00	杭州北京（现货）
Bellancom-15344		￥0.00	杭州北京（现货）

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(R,R)-BD-AcAc 2 酮酯; (R,R-Ketone Ester)

产品介绍

(R,R)-BD-AcAc 2((R,R)-Ketone Ester) 是一种酮单酯，可作为口服营养酮的来源。小鼠口服 (R,R)-BD-AcAc 2 后可提高血浆 β-羟基丁酸和乙酰乙酸水平、血糖、血液钠离子水平和血肌酐水平。(R,R)-BD-AcAc 2 可在一定程度上预防脓毒症小鼠的肌无力。(R,R)-BD-AcAc 2 具有提高动物机体运动能力和耐力的潜力。(R,R)-BD-AcAc 2 还可用于研究帕金森病或糖尿病。

生物活性

(R,R)-BD-AcAc 2 ((R,R)-Ketone Ester), a ketone monoester, can be used as a source of oral nutritional ketones. (R,R)-BD-AcAc 2 can elevate plasma levels of β-hydroxybutyrate and acetoacetate, blood glucose, blood Na⁺ levels and blood creatinine levels after oral administration in mice. (R,R)-BD-AcAc 2 can partly prevent muscle weakness in septic mice. (R,R)-BD-AcAc 2 has potential to improve exercise performance and endurance in animal body. (R,R)-BD-AcAc 2 can also be used to research Parkinson’s disease or diabetes.

体外研究

体内研究

(R,R)-BD-AcAc 2 (D-3HHB) increases specific muscle force, moderately raises blood glucose concentrations, lowers Aldh3b2 gene expression, increases blood Na⁺ levels and blood creatinine levels, and reduces plasma free fatty acid concentrations.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Septic mice
Dosage:	10, 20, 40 and 80 mmol/kg/day
Administration:	PO
Result:	Increased specific muscle force as compared with placebo to 93% of healthy control levels at 40 mmol/kg/day. Resulted in moderately higher blood glucose concentrations as compared with placebo at 40 mmol/kg/day. Lowered Aldh3b2 gene expression than with placebo at 40 mmol/kg/day. Evoked a moderate further increase in blood Na⁺ levels and increased blood creatinine levels at 20 mmol/kg/day. Reduced plasma free fatty acid concentrations by 10 or 20 mmol/kg/day. Hepatic gene expression levels of Aldh1a7 was also reduced by sepsis but increased by D-3HHB.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Septic mice
Dosage:	10, 20, 40 and 80 mmol/kg/day
Administration:	PO
Result:	Increased specific muscle force as compared with placebo to 93% of healthy control levels at 40 mmol/kg/day. Resulted in moderately higher blood glucose concentrations as compared with placebo at 40 mmol/kg/day. Lowered Aldh3b2 gene expression than with placebo at 40 mmol/kg/day. Evoked a moderate further increase in blood Na⁺ levels and increased blood creatinine levels at 20 mmol/kg/day. Reduced plasma free fatty acid concentrations by 10 or 20 mmol/kg/day. Hepatic gene expression levels of Aldh1a7 was also reduced by sepsis but increased by D-3HHB.

性状

Liquid

溶解性数据

In Vitro:

H₂O : 100 mg/mL (567.50 mM; Need ultrasonic)

DMSO : 100 mg/mL (567.50 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.6750 mL	28.3752 mL	56.7505 mL
5 mM	1.1350 mL	5.6750 mL	11.3501 mL
10 mM	0.5675 mL	2.8375 mL	5.6750 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (567.50 mM); Clear solution; Need ultrasonic
2.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 5.5 mg/mL (31.21 mM); Clear solution

此方案可获得 ≥ 5.5 mg/mL (31.21 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 55.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
3.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 5.5 mg/mL (31.21 mM); Clear solution

此方案可获得 ≥ 5.5 mg/mL (31.21 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 55.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
4.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 5.5 mg/mL (31.21 mM); Clear solution

此方案可获得 ≥ 5.5 mg/mL (31.21 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 55.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。