(+)-Coclaurine ((+)-(R)-Coclaurine) hydrochloride, benzyltetrahydroisoquinoline alkaloid isolated from a variety of plant sources. (+)-Coclaurine hydrochloride has anti-aging activity.

An intracerebroventricular injection of (+)-Coclaurine (d-Coclaurine; 50 μg) hydrochloride produces a slight increase in 3,4-dihydroxyphenylacetic acid level and a significant increase in homovanillic acid level in the mouse striatum. (+)-Coclaurine hydrochloride blocks postsynaptic but not presynaptic dopamine receptors in the mouse striatum.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

An intracerebroventricular injection of (+)-Coclaurine (d-Coclaurine; 50 μg) hydrochloride produces a slight increase in 3,4-dihydroxyphenylacetic acid level and a significant increase in homovanillic acid level in the mouse striatum. (+)-Coclaurine hydrochloride blocks postsynaptic but not presynaptic dopamine receptors in the mouse striatum.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

• . Siva S Panda, et al. Protective effects of Aporosa octandra bark extract against D-galactose induced cognitive impairment and oxidative stress in mice. Heliyon. 2018 Nov 30;4(11):e00951.  [Content Brief]

  . H Watanabe, et al. Effects of d-coclaurine and d-reticuline, benzyltetrahydroisoquinoline alkaloids, on levels of 3,4-dihydroxyphenylacetic acid and homovanillic acid in the mouse striatum. J Pharmacobiodyn. 1983 Oct;6(10):793-6.  [Content Brief]