Quipazine 2-(1-哌嗪基喹啉)|cas:4774-24-7|西域试剂

Quipazine 2-(1-哌嗪基喹啉)

产品编号：Bellancom-W028142| CAS NO：4774-24-7| 分子式：C₁₃H₁₅N₃| 分子量：213.28

奎帕嗪是一种5-HT激动剂，其Ki值为1.4nM，用于在大鼠中取代[3H]GR65630的5-HT3R。Quipazine显示出对SARS-CoV-2的抗病毒活性，EC50为31.64μM。奎帕嗪在外周模型中表现为5-HT3R激动剂。奎帕嗪可用于神经疾病研究。

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-W028142		￥500.00	杭州北京（现货）
Bellancom-W028142		￥700.00	杭州北京（现货）

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Quipazine 2-(1-哌嗪基喹啉)

产品介绍	Quipazine 是一种 5-HT 激动剂，取代大鼠内皮层中 5-HT3R 的 [3H]GR65630 的 K_i 值为 1.4 nM。Quipazine 对 SARS-CoV-2 具有抗病毒活性，EC₅₀ 值为 31.64 μM。Quipazine 在外周模型中表现为 5-HT3R 的激动剂，可用于神经疾病研究。
生物活性	Quipazine is a 5-HT agonist with a K_i value of 1.4 nM for displaces [3H]GR65630 from 5-HT3R in rat. Quipazine shows antiviral activity against SARS-CoV-2 with an EC₅₀ of 31.64 μM. Quipazine behaves as a 5-HT3R agonist in peripheral models. Quipazine can be used for neurological disease research^[4].
体外研究	Quipazine 对 5-HT1 和 5-HT2 具有结合效能，K_i 值均为 230 nM。 Quipazine 取代大鼠内皮层中 5-HT3R 的 [3H]GR65630，K_i 值为 1.4 nM。 Quipazine 对大鼠迷走神经具有拮抗作用，对 5-HT2，5-HT1 以及抑制 5-HT 释放的 pIC₅₀ 值分别为 6.1，6.49 和 6.17^[4]。西域 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究	Quipazine (2.5，5 和 7.5 mg/kg，每个剂量各一次；腹腔注射) 影响雄性和雌性大鼠对不同宏量营养素饮食的膳食自我选择。西域 has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究	Quipazine (2.5，5 和 7.5 mg/kg，每个剂量各一次；腹腔注射) 影响雄性和雌性大鼠对不同宏量营养素饮食的膳食自我选择。西域 has not independently confirmed the accuracy of these methods. They are for reference only.
性状	Solid
溶解性数据
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
参考文献	. Mok E, et al. Effect of quipazine, a selective 5-HT3 agonist, on dietary self-selection of different macronutrient diets in male and female rats. Appetite. 2000 Jun;34(3):313-25. [Content Brief] . Günther S, et al. X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease. Science. 2021 May 7;372(6542):642-646. [Content Brief] . Glennon RA, et al. 5-HT1 and 5-HT2 binding characteristics of some quipazine analogues. J Med Chem. 1986 Nov;29(11):2375-80. [Content Brief] [4]. Ireland SJ, Tyers MB. Pharmacological characterization of 5-hydroxytryptamine-induced depolarization of the rat isolated vagus nerve. Br J Pharmacol. 1987 Jan;90(1):229-38. [Content Brief]