E1R|cas:1301211-78-8|西域试剂

E1R,99.28%

产品编号：Bellancom-116463| CAS NO：1301211-78-8| 分子式：C₁₃H₁₆N₂O₂| 分子量：232.28

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货号	价格	库存与货期
Bellancom-116463	￥3500.00	杭州北京（现货）
Bellancom-116463	￥5500.00	杭州北京（现货）
Bellancom-116463	￥9900.00	杭州北京（现货）
Bellancom-116463	￥16500.00	杭州北京（现货）
Bellancom-116463	￥22500.00	杭州北京（现货）

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E1R

产品介绍

E1R 是一种 sigma-1 受体的正变构调节剂 (Sig1R PAM)，具有认知增强效果。

生物活性

E1R is a positive allosteric modulator of sigma-1 receptors (Sig1R PAM) with cognition-enhancing activity.

体外研究

The only target for E1R (inhibition or enhancement of radioligand binding exceeding 20%) is the sigma receptor. 10 μM E1R does not displace the radioligand, but instead increases the specific binding of a non-selective radioligand ([³H]1,3-di(2-tolyl)guanidine) for the sigma receptor by 38% in Jurkat cells.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

E1R demonstrates efficacy against scopolamine-induced cholinergic dysfunction in mice. Treatment with E1R (0.1-10 mg/kg; administered i.p. 60 min before the training session) significantly improves cognitive function in a dose-related manner in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male ICR and Balb/c mice weighed 23-25 g
Dosage:	0.1, 1 and 10 mg/kg
Administration:	Administered i.p. 60 min before the training session
Result:	Treatment at doses of 1 and 10 mg/kg increased retention latency by 194 and 211%, respectively, compared with the control group.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male ICR and Balb/c mice weighed 23-25 g
Dosage:	0.1, 1 and 10 mg/kg
Administration:	Administered i.p. 60 min before the training session
Result:	Treatment at doses of 1 and 10 mg/kg increased retention latency by 194 and 211%, respectively, compared with the control group.

性状

Solid

溶解性数据

In Vitro:

DMSO : 60 mg/mL (258.31 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.3051 mL	21.5257 mL	43.0515 mL
5 mM	0.8610 mL	4.3051 mL	8.6103 mL
10 mM	0.4305 mL	2.1526 mL	4.3051 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式