Progabide 普罗加比; SL 76002,99.42%
产品编号：Bellancom-A0173| CAS NO：62666-20-0| 分子式：C17H16ClFN2O2| 分子量：334.77
Progabide 是一种 γ-氨基丁酸 (GABA) 受体激动剂。
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Progabide 普罗加比; SL 76002
| 产品介绍 | Progabide 是一种 γ-氨基丁酸 (GABA) 受体激动剂。 | ||||||||||||||||
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| 生物活性 | Progabide is a gamma-aminobutyric acid receptor (GABA) agonist. | ||||||||||||||||
| 体外研究 | |||||||||||||||||
| 体内研究 |
Progabide is a gamma-aminobutyric acid receptor (GABA) agonist. Doses of 50, 100 and 200 mg/kg Progabide given IP to male Wistar rats increase the plasma corticosterone levels by 244, 365 and 476% respectively (t=6.44 to12.55, p<0.01). 10 mg/kg of Progabide fails to change the concentration of corticosterone in plasma (t=0.76, N.S.). The increased plasma corticosterone level induced by administration of 200 mg/kg Progabide is evident 30 (t=2.625, p<0.05), 60 (t=13.13, p<0.001) and 120 min (t=4.07, p<0.01) after drug injection, but returns to the control value 240 min after drug injection (t=0.86, N.S.). The greatest corticosterone rise (compare with the corresponding control) is reached 60 min following the administration of Progabide. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||||||
| 体内研究 |
Progabide is a gamma-aminobutyric acid receptor (GABA) agonist. Doses of 50, 100 and 200 mg/kg Progabide given IP to male Wistar rats increase the plasma corticosterone levels by 244, 365 and 476% respectively (t=6.44 to12.55, p<0.01). 10 mg/kg of Progabide fails to change the concentration of corticosterone in plasma (t=0.76, N.S.). The increased plasma corticosterone level induced by administration of 200 mg/kg Progabide is evident 30 (t=2.625, p<0.05), 60 (t=13.13, p<0.001) and 120 min (t=4.07, p<0.01) after drug injection, but returns to the control value 240 min after drug injection (t=0.86, N.S.). The greatest corticosterone rise (compare with the corresponding control) is reached 60 min following the administration of Progabide. 西域 has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||||||
| 性状 | Solid | ||||||||||||||||
| 溶解性数据 |
In Vitro:
DMSO : 250 mg/mL (746.78 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 | ||||||||||||||||
| 运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
| 储存方式 |
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| 参考文献 | |||||||||||||||||
| 海关编码 | 2925290090 |
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62666-20-0 |
| 文献：DE2634288 , ; Chem.Abstr., , vol. 86, # 189530 |
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62666-20-0 |
| 文献：DE2634288 , ; Chem.Abstr., , vol. 86, # 189530 |
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