MK-6884|cas:2102194-04-5|西域试剂

MK-6884,99.11%

产品编号：Bellancom-141899| CAS NO：2102194-04-5| 分子式：C₂₅H₂₅N₅O| 分子量：411.50

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货号	价格	库存与货期
Bellancom-141899	￥3800.00	杭州北京（现货）
Bellancom-141899	￥6000.00	杭州北京（现货）
Bellancom-141899	￥11500.00	杭州北京（现货）

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MK-6884

产品介绍

MK-6884 是一种 M4 毒蕈碱受体正变构调节剂 (PAM)，其 K_i 值为 0.19 nM。MK-6884 可用于神经退行性疾病的研究。MK-6884 可用 ¹¹C 放射标记作为正电子发射计算机断层扫描显像剂。

生物活性

MK-6884 is a M4 muscarinic receptor positive allosteric modulator (PAM) with a K_i value of 0.19 nM. MK-6884 can be used for the research of the neurodegenerative diseases. MK-6884 can be conveniently radiolabeled with carbon-11 and as a positron emission tomography (PET) imaging agent.

体外研究

MK-6884 (compound 13; 0-22 µM) is a PAM of ACh function in a cell-based Ca²⁺ mobilization assay, with an EC₅₀ of 27 nM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

[¹¹C]MK-6884 (compound 13) shows non-displaceable binding potential (BP_ND) of 0.83 in rhesus monkeys.
[¹¹C]MK-6884 (approximately 185 MBq, <2 μg; single intravenous) distributes on the known presence of M4 receptors in the rhesus monkeys brain.
[¹¹C]MK-688 can penetrate the blood-brain barrier in monkeys.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

THF : 3.33 mg/mL (8.09 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.4301 mL	12.1507 mL	24.3013 mL
5 mM	0.4860 mL	2.4301 mL	4.8603 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式