Nemifitide diTFA INN 00835 diTFA|cas:204992-09-6|西域试剂

Nemifitide diTFA INN 00835 diTFA,99.13%

产品编号：Bellancom-105077A| CAS NO：204992-09-6| 分子式：C₃₇H₄₅F₇N₁₀O₁₀| 分子量：922.80

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货号	价格	库存与货期
Bellancom-105077A	￥2500.00	杭州北京（现货）
Bellancom-105077A	￥4500.00	杭州北京（现货）
Bellancom-105077A	￥16500.00	杭州北京（现货）

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Nemifitide diTFA INN 00835 diTFA

产品介绍

Nemifitide diTFA (INN 00835 diTFA) 是一种合成的五肽抗抑郁药，具有迅速起效的潜力。Nemifitide diTFA 是黑色素细胞抑制因子 (MIF) 的肽类似物。Nemifitide diTFA 可以透过血脑屏障。

生物活性

Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF). Nemifitide diTFA can cross the blood-brain barrier.

体外研究

Nemifitide diTFA (INN 00835 diTFA) and its active metabolite (M1) bind at micromolar concentrations to several receptors including the 5-HT_2A, 5-HT_2C, melanocortin MC4, MC5 and bombesin.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Nemifitide diTFA (INN 00835 diTFA; 0.3 mg/kg; IP; daily; for 14 days) significantly increases swimming in the FSL rats after just 5 days of treatment and has long-lasting effect.
Nemifitide diTFA (0.0125-15.0 mg/kg) significantly increases swimming in the FSL rats at both low (0.025-0.3 mg/kg) and high (3.0-15.0 mg/kg) doses but not at intermediate (0.4-2.4 mg/kg) doses.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Flinders Sensitive Line (FSL) rat weighing 280-320 g
Dosage:	0.3 mg/kg
Administration:	IP; daily; for 14 days
Result:	Significantly increased swimming in the FSL rats after just 5 days of treatment and had long-lasting effect.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Flinders Sensitive Line (FSL) rat weighing 280-320 g
Dosage:	0.3 mg/kg
Administration:	IP; daily; for 14 days
Result:	Significantly increased swimming in the FSL rats after just 5 days of treatment and had long-lasting effect.

性状

Solid

溶解性数据

In Vitro:

H₂O : 250 mg/mL (270.91 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.0837 mL	5.4183 mL	10.8366 mL
5 mM	0.2167 mL	1.0837 mL	2.1673 mL
10 mM	0.1084 mL	0.5418 mL	1.0837 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light