Dichlorophenyl-ABA|cas:18201-65-5|西域试剂

Dichlorophenyl-ABA,99.0%

产品编号：Bellancom-113950| CAS NO：18201-65-5| 分子式：C₁₃H₉Cl₂NO₂| 分子量：282.12

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
Bellancom-113950		￥2100.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

Dichlorophenyl-ABA

产品介绍

Dichlorophenyl-ABA 是转甲状腺素蛋白 (TTR) 淀粉样蛋白原纤维形成的抑制剂，可抑制表达 TTR L55P 的细胞中 80％以上的聚集体形成。

生物活性

Dichlorophenyl-ABA is an inhibitor of transthyretin (TTR) amyloid fibril formation, inhibiting aggregate formation in more than 80% in TTR L55P-expressing cells.

体外研究

Dichlorophenyl-ABA (DCPA) is able to prevent L55P aggregate formation in the conditioned medium. With regard to the ultrastructural analysis, Dichlorophenyl-ABA does not show an inhibitory effect as high as DFPB and benzoxazole, indicating that the Y78F mutant may not be as sensitive to this drug as TTR L55P and V30M are.
Dichlorophenyl-ABA is the best stabilizers of V30M tetramers in plasma from carriers of this mutant, and clearly inhibit aggregation in the cellular system. Therefore Dichlorophenyl-ABA is promising for the treatment of valine at position 30 (V30M)-associated familial amyloidotic polyneuropathy (FAP) but need to undergo further stages of drug development to overcome their toxicity.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (354.46 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.5446 mL	17.7230 mL	35.4459 mL
5 mM	0.7089 mL	3.5446 mL	7.0892 mL
10 mM	0.3545 mL	1.7723 mL	3.5446 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式