SC 51089 free base|cas:146033-03-6|西域试剂

SC 51089 free base,98.64%

产品编号：Bellancom-108563A| CAS NO：146033-03-6| 分子式：C₂₂H₁₉ClN₄O₃| 分子量：422.86

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-108563A	￥1000.00	杭州北京（现货）
Bellancom-108563A	￥1600.00	杭州北京（现货）
Bellancom-108563A	￥3500.00	杭州北京（现货）
Bellancom-108563A	￥6200.00	杭州北京（现货）
Bellancom-108563A	￥10900.00	杭州北京（现货）

增值税发票√顺丰快递√订货电话：18601927057

SC 51089 free base

产品介绍

SC 51089 free base 是一种选择性的前列腺素受体 EP1 拮抗剂，对 EP1，TP，EP3 和 FP 受体的 K_i 值分别为 1.3，11.2，17.5 和 61.1 μM。SC 51089 free base 具有神经保护活性。

生物活性

SC 51089 free base is a selective antagonist of prostaglandin E₂ EP1 receptor, with K_is of 1.3, 11.2, 17.5, and 61.1 μM for EP1, TP, EP3, and FP receptors, respectively. SC 51089 free base exhibits neuroprotective activity.

体外研究

SC 51089 free base (5 μM; 24 h) 减弱前列腺素 E2 (PGE2) 诱导的暴露于 t-BuOOH 的神经元细胞死亡。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

SC 51089 free base (40 μg/kg; infused i.p. for 28 d) 改善 HD 小鼠运动协调和平衡功能障碍，并挽救长期记忆缺陷。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	R6/1 mouse model of Huntington's disease (HD), from 13 to 18 weeks of age
Dosage:	40 μg/kg/day
Administration:	Infused i.p. at a rate of 0.11 μL/h during 28 days by osmotic mini-pump system
Result:	Ameliorated motor coordination and balance dysfunction. Rescued long-term memory deficit. Improved the expression of specific synaptic markers. Reduced the number of huntingtin nuclear inclusions in the striatum and hippocampus.

体内研究

SC 51089 free base (40 μg/kg; infused i.p. for 28 d) 改善 HD 小鼠运动协调和平衡功能障碍，并挽救长期记忆缺陷。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	R6/1 mouse model of Huntington's disease (HD), from 13 to 18 weeks of age
Dosage:	40 μg/kg/day
Administration:	Infused i.p. at a rate of 0.11 μL/h during 28 days by osmotic mini-pump system
Result:	Ameliorated motor coordination and balance dysfunction. Rescued long-term memory deficit. Improved the expression of specific synaptic markers. Reduced the number of huntingtin nuclear inclusions in the striatum and hippocampus.

性状

Solid

溶解性数据

In Vitro:

DMSO : 100 mg/mL (236.48 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3648 mL	11.8242 mL	23.6485 mL
5 mM	0.4730 mL	2.3648 mL	4.7297 mL
10 mM	0.2365 mL	1.1824 mL	2.3648 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

参考文献