Ro60-0175|cas:169675-08-5|西域试剂

Ro60-0175,99.98%

产品编号：Bellancom-123838| CAS NO：169675-08-5| 分子式：C₁₁H₁₂ClFN₂| 分子量：226.68

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	价格	库存与货期
Bellancom-123838	￥3200.00	杭州北京（现货）
Bellancom-123838	￥5100.00	杭州北京（现货）
Bellancom-123838	￥10500.00	杭州北京（现货）

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Ro60-0175

产品介绍

Ro60-0175 是一种有效的选择性 5-HT_2C 受体激动剂。Ro60-0175 降低了成瘾性。

生物活性

Ro60-0175 is a potent and selective agonist of 5-HT_2C receptor. Ro60-0175 reduces self-administration.

体外研究

体内研究

Ro60-0175（1 mg/kg；皮下注射）保留了在药物治疗组的对照动物中观察到的规律性反应，但药物治疗的动物更早达到它们的转折点。
Ro60-0175（0.3、1 和 3 mg/kg；皮下注射）显着降低恢复组对主动杠杆的响应。
Ro60-0175（0.5mg/kg SB242084；1mg/kg Ro60-0175；皮下注射）与恢复组中的载体相比降低了反应，并且通过 SB242084 预处理可以防止这种效应。对于对非活动杠杆的响应，没有显着的主效应或交互作用。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male Sprague-Dawley rats (280-320 g)
Dosage:	1 mg/kg
Administration:	s.c.
Result:	Preserved the regularity of responding seen in control animals in drug-treated group, but drug-treated animals reached their break-points earlier.

Animal Model:	Adult male Sprague-Dawley rats (280-320 g)
Dosage:	0.5 mg/kg (SB242084), 1 mg/kg (Ro60-0175)
Administration:	s.c. (Ro60-0175), i.p. (SB242084)
Result:	Reduced responding for cocaine and effect was reversed by SB242084.

Animal Model:	Adult male Sprague-Dawley rats (280-320 g)
Dosage:	0.3, 1, and 3 mg/kg (Ro60-0175), 1 mg/kg (yohimbine)
Administration:	s.c. (Ro60-0175), i.p. (yohimbine)
Result:	Showed yohimbine treatment alone increased responding relative to vehicle injection, and the response was attenuated dose dependently by Ro60-0175.

Animal Model:	Adult male Sprague-Dawley rats (280-320 g)
Dosage:	0.5 mg/kg (SB242084), 1 mg/kg (Ro60-0175), 1 mg/kg (yohimbine)
Administration:	s.c. (Ro60-0175), i.p. (yohimbine), i.p. (SB242084)
Result:	Ro60-0175 reduced responding and that this effect was prevented by SB242084 pretreatment.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male Sprague-Dawley rats (280-320 g)
Dosage:	1 mg/kg
Administration:	s.c.
Result:	Preserved the regularity of responding seen in control animals in drug-treated group, but drug-treated animals reached their break-points earlier.

Animal Model:	Adult male Sprague-Dawley rats (280-320 g)
Dosage:	0.5 mg/kg (SB242084), 1 mg/kg (Ro60-0175)
Administration:	s.c. (Ro60-0175), i.p. (SB242084)
Result:	Reduced responding for cocaine and effect was reversed by SB242084.

Animal Model:	Adult male Sprague-Dawley rats (280-320 g)
Dosage:	0.3, 1, and 3 mg/kg (Ro60-0175), 1 mg/kg (yohimbine)
Administration:	s.c. (Ro60-0175), i.p. (yohimbine)
Result:	Showed yohimbine treatment alone increased responding relative to vehicle injection, and the response was attenuated dose dependently by Ro60-0175.

Animal Model:	Adult male Sprague-Dawley rats (280-320 g)
Dosage:	0.5 mg/kg (SB242084), 1 mg/kg (Ro60-0175), 1 mg/kg (yohimbine)
Administration:	s.c. (Ro60-0175), i.p. (yohimbine), i.p. (SB242084)
Result:	Ro60-0175 reduced responding and that this effect was prevented by SB242084 pretreatment.

性状

Solid

溶解性数据

In Vitro:

DMSO : 125 mg/mL (551.44 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	4.4115 mL	22.0575 mL	44.1151 mL
5 mM	0.8823 mL	4.4115 mL	8.8230 mL
10 mM	0.4412 mL	2.2058 mL	4.4115 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.08 mg/mL (9.18 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (9.18 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。
将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液
2.

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.08 mg/mL (9.18 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (9.18 mM，饱和度未知) 的澄清溶液。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。
将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
3.

请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.08 mg/mL (9.18 mM); Clear solution

此方案可获得 ≥ 2.08 mg/mL (9.18 mM，饱和度未知) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。
以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。