SMND-309|cas:1065559-56-9|西域试剂

SMND-309,96.81%

产品编号：Bellancom-13056| CAS NO：1065559-56-9| 分子式：C₁₈H₁₄O₈| 分子量：358.30

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-13056		￥1841.00	杭州北京（现货）
Bellancom-13056		￥3274.00	杭州北京（现货）

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SMND-309

产品介绍

SMND-309 是丹酚酸 B 的代谢产物，在神经元和永久性大脑动脉闭塞大鼠中具有保护神经的作用。

生物活性

SMND-309 is a metabolite of salvianolic acid B, and exhibits neuroprotective effects in cultured neurons and in permanent middle cerebral artery occlusion rats.

体外研究

体内研究

SMND-309 (2.5-10 mg/kg; oral intragastric; once a day; for 4 weeks; male Sprague-Dawley rats) treatment ameliorates liver function and decreases the elevation of serum hyaluronic acid, laminin, procollagen type III levels and hydroxyproline content in liver tissue. SMND-309 also decreases the elevation in the malondialdehyde level and restored the decrease in superoxide dismutase and glutathione peroxidase activities. SMND-309 treatment reduces the liver damage and the liver fibrosis grade. SMND-309 treatment powerfully down-regulated the expression of connective tissue growth factor (CTGF) in serum and liver.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats (180-200 g) with carbon tetrachloride
Dosage:	2.5 mg/kg, 5 mg/kg and 10 mg/kg
Administration:	Oral intragastric; once a day; for 4 weeks
Result:	The antifibrotic mechanisms might be associated with its ability to suppress the expression of CTGF as well as scavenge lipid peroxidation products and increase endogenous antioxidant enzyme activity.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats (180-200 g) with carbon tetrachloride
Dosage:	2.5 mg/kg, 5 mg/kg and 10 mg/kg
Administration:	Oral intragastric; once a day; for 4 weeks
Result:	The antifibrotic mechanisms might be associated with its ability to suppress the expression of CTGF as well as scavenge lipid peroxidation products and increase endogenous antioxidant enzyme activity.

性状

Solid

溶解性数据

In Vitro:

DMSO : ≥ 3.7 mg/mL (10.33 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7910 mL	13.9548 mL	27.9096 mL
5 mM	0.5582 mL	2.7910 mL	5.5819 mL
10 mM	0.2791 mL	1.3955 mL	2.7910 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式