MOMIPP|cas:1363421-46-8|西域试剂

MOMIPP,99.37%

产品编号：Bellancom-119624| CAS NO：1363421-46-8| 分子式：C₁₈H₁₆N₂O₂| 分子量：292.33

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货号	价格	库存与货期
Bellancom-119624	￥2700.00	杭州北京（现货）
Bellancom-119624	￥4300.00	杭州北京（现货）
Bellancom-119624	￥8100.00	杭州北京（现货）
Bellancom-119624	￥12000.00	杭州北京（现货）

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MOMIPP

产品介绍

MOMIPP，一种巨胞饮作用的诱导剂，是一种 PIKfyve 抑制剂。MOMIPP 可穿过血脑屏障 (BBB)。

生物活性

MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB).

体外研究

MOMIPP can induce intense macropinocytosis, leading to methuosis in cultured glioblastoma cells at low micromolar concentrations.
In U373 and Hs683 cell lines, 3 µM for MOMIPP induces cell vacuolization.
MOMIPP (10 μM) causes early disruptions of glucose uptake and glycolytic metabolism. MOMIPP selectively activates the JNK1/2 stress kinase pathway, resulting in phosphorylation of c-Jun, Bcl-2 and Bcl-xL.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	U251 cells
Concentration:	10 μM
Incubation Time:	4 h or 24 h
Result:	Activated the JNK stress kinase pathway.

体内研究
(In Vivo)

MOMIPP (80 mg/kg; i.p.; once daily; for 15 consecutive days) shows moderately effective in suppressing progression of intracerebral glioblastoma xenografts.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Athymic CrTac:NCR-Foxn1 mice (female, 7-8 weeks)
Dosage:	80 mg/kg
Administration:	i.p.; once daily; for 15 consecutive days
Result:	Suppressed progression of intracerebral glioblastoma xenografts.

体内研究

MOMIPP (80 mg/kg; i.p.; once daily; for 15 consecutive days) shows moderately effective in suppressing progression of intracerebral glioblastoma xenografts.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Athymic CrTac:NCR-Foxn1 mice (female, 7-8 weeks)
Dosage:	80 mg/kg
Administration:	i.p.; once daily; for 15 consecutive days
Result:	Suppressed progression of intracerebral glioblastoma xenografts.

体内研究

MOMIPP (80 mg/kg; i.p.; once daily; for 15 consecutive days) shows moderately effective in suppressing progression of intracerebral glioblastoma xenografts.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Athymic CrTac:NCR-Foxn1 mice (female, 7-8 weeks)
Dosage:	80 mg/kg
Administration:	i.p.; once daily; for 15 consecutive days
Result:	Suppressed progression of intracerebral glioblastoma xenografts.

性状

Solid

溶解性数据

In Vitro:

DMSO : 31.25 mg/mL (106.90 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.4208 mL	17.1040 mL	34.2079 mL
5 mM	0.6842 mL	3.4208 mL	6.8416 mL
10 mM	0.3421 mL	1.7104 mL	3.4208 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式