GDC-0310|cas:1788063-52-4|西域试剂

GDC-0310,99.80%

产品编号：Bellancom-139081| CAS NO：1788063-52-4| 分子式：C₂₅H₂₉Cl₂FN₂O₄S| 分子量：543.48

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作
Bellancom-139081		￥5000.00	杭州北京（现货）
Bellancom-139081		￥8500.00	杭州北京（现货）

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GDC-0310

产品介绍

GDC-0310 是选择性的 Na_v1.7 酰磺酰胺抑制剂，其对 hNa_v1.7 的 IC₅₀ 值为 0.6 nM。

生物活性

GDC-0310 is a selective acyl-sulfonamide Na_v1.7 inhibitor, with an IC₅₀ of 0.6 nM for hNa_v1.7.

体外研究

GDC-0310 exhibits an EC₅₀ of 1.1 μM in vivo and a K_i of 1.8 nM for Na_v1.7.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

GDC-0310 shows substantially improved Na_v selectivity and ADME properties.
GDC-0310 exhibits t1/2 values of 5 h, 46 h and 4.4 h in rat (5 mg/kg, iv), dog (1 mg/kg, iv) and cynomolgus monkeys (2 mg/kg, iv), respectively.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 4 mg/mL (7.36 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.8400 mL	9.2000 mL	18.3999 mL
5 mM	0.3680 mL	1.8400 mL	3.6800 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式