Cyproheptadine|cas:129-03-3|西域试剂

Cyproheptadine,99.86%

产品编号：Bellancom-B1622| CAS NO：129-03-3| 分子式：C₂₁H₂₁N| 分子量：287.40

赛庚啶是一种口服有效的5-HT2A受体拮抗剂，具有抗抑郁和抗腐烂作用。赛庚啶具有抗血小板和血栓保护活性。赛庚啶可用于研究血栓栓塞性疾病。

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货号	价格	库存与货期
Bellancom-B1622	￥800.00	杭州北京（现货）
Bellancom-B1622	￥1300.00	杭州北京（现货）
Bellancom-B1622	￥2400.00	杭州北京（现货）
Bellancom-B1622	￥3500.00	杭州北京（现货）
Bellancom-B1622	￥5200.00	杭州北京（现货）

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Cyproheptadine

产品介绍

Cyproheptadine 是一种有效的口服活性 5-HT_2A 受体 拮抗剂，具有抗抑郁和抗血清素作用。Cyproheptadine 具有抗血小板活性。Cyproheptadine 可以用于血栓栓塞性疾病的研究。

生物活性

Cyproheptadine is a potent and orally active 5-HT_2A receptor antagonist, with antidepressant and antiserotonergic effects. Cyproheptadine has antiplatelet and thromboprotective activities. Cyproheptadine can be used for the research of thromboembolic disorders.

体外研究

Cyproheptadine (0.01-100 nM; 1 minute) dose-dependently inhibits serotonin-enhanced ADP-induced mouse platelet aggregation in vitro.
Cyproheptadine (10 nM) has the ability to inhibit 15 µM serotonin-enhanced ADP-induced (1 µM) tyrosine phosphorylation in platelets in vitro.
Cyproheptadine inhibits human platelet PS exposure (Annexin V), P-selectin, and GPIIb-IIIa (PAC-1 binding) activation in vitro.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Cyproheptadine (1 mg/kg; i.p.; daily, for 5 days; C57BL/6 mice) exerts thromboprotective properties in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice (8-10 weeks old)
Dosage:	1 mg/kg
Administration:	Intraperitoneal injection; daily, for 5 days
Result:	Prolonged occlusion times and tail bleeding times in mice.

体内研究

Cyproheptadine (1 mg/kg; i.p.; daily, for 5 days; C57BL/6 mice) exerts thromboprotective properties in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	C57BL/6 mice (8-10 weeks old)
Dosage:	1 mg/kg
Administration:	Intraperitoneal injection; daily, for 5 days
Result:	Prolonged occlusion times and tail bleeding times in mice.

性状

Solid

溶解性数据

In Vitro:

DMSO : 3.17 mg/mL (11.03 mM; ultrasonic and warming and adjust pH to 3 with HCl and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.4795 mL	17.3974 mL	34.7947 mL
5 mM	0.6959 mL	3.4795 mL	6.9589 mL
10 mM	0.3479 mL	1.7397 mL	3.4795 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式