Cu(II)GTSM|cas:68341-14-0|西域试剂

Cu(II)GTSM,95.0%

产品编号：Bellancom-139324| CAS NO：68341-14-0| 分子式：C₆H₁₀CuN₆S₂| 分子量：293.86

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货号	价格	库存与货期
Bellancom-139324	￥1200.00	杭州北京（现货）
Bellancom-139324	￥2000.00	杭州北京（现货）
Bellancom-139324	￥4200.00	杭州北京（现货）
Bellancom-139324	￥6800.00	杭州北京（现货）
Bellancom-139324	￥10800.00	杭州北京（现货）

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Cu(II)GTSM

产品介绍

Cu(II)GTSM 是一种细胞通透性铜复合物，可显著抑制 GSK3β。Cu(II)GTSM 抑制 Amyloid-β 寡聚体 (AβOs)，降低 tau 磷酸化。Cu(II)GTSM 也降低了 Amyloid-β 三聚体的丰度。Cu(II)GTSM 可以被作为一种潜在的抗癌和抗菌剂。

生物活性

Cu(II)GTSM, a cell-permeable Cu-complex, significantly inhibits GSK3β. Cu(II)GTSM inhibits Amyloid-β oligomers (AβOs) and decreases tau phosphorylation. Cu(II)GTSM also decreases the abundance of Amyloid-β trimers. Cu(II)GTSM is a potential anticancer and antimicrobial agent.

体外研究

Cu(II)GTSM induces GSK3β phosphorylation at serine-9 (ser9) via its upstream kinase, protein kinase B (Akt), and aslo increases the phosphorylation of the associated extracellular signal-related kinase 1/2 (ERK1/2) in SH-SY5Y cells.
Tau phosphorylation at ser404 was decreased in CuII(gtsm)-treated cells by 64%.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis

Cell Line:	SH-SY5Y cells
Concentration:	25 μM
Incubation Time:	2 hours
Result:	Inhibits GSK3β and decreases Tau phosphorylation.

体内研究
(In Vivo)

Cu(II)GTSM decreases brain Aβ trimer levels in AD mice, and can reverse cognitive deficits in APP/PS1 transgenic AD mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	AD mice (K670N, M671L; 5-6 months old)
Dosage:	10 mg/kg
Administration:	Daily; p.o.
Result:	Restores cognitive performance of the AD mice to levels expected for healthy, cognitively normal mice.

体内研究

Cu(II)GTSM decreases brain Aβ trimer levels in AD mice, and can reverse cognitive deficits in APP/PS1 transgenic AD mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	AD mice (K670N, M671L; 5-6 months old)
Dosage:	10 mg/kg
Administration:	Daily; p.o.
Result:	Restores cognitive performance of the AD mice to levels expected for healthy, cognitively normal mice.

体内研究

Cu(II)GTSM decreases brain Aβ trimer levels in AD mice, and can reverse cognitive deficits in APP/PS1 transgenic AD mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	AD mice (K670N, M671L; 5-6 months old)
Dosage:	10 mg/kg
Administration:	Daily; p.o.
Result:	Restores cognitive performance of the AD mice to levels expected for healthy, cognitively normal mice.