Opipramol 奥匹哌醇; Ensidon; G-33040|cas:315-72-0|西域试剂

Opipramol 奥匹哌醇; Ensidon; G-33040,99.0%

产品编号：Bellancom-118901| CAS NO：315-72-0| 分子式：C₂₃H₂₉N₃O| 分子量：363.50

奥普拉莫（Ensidon）是一种非典型的三环抗抑郁药（TCA）。奥普拉莫主要作为西格玛（σ）受体激动剂，可以与Ki值为50nM的西格玛识别位点有效相互作用。奥普拉莫可用于广泛性焦虑症（GAD）的研究。

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-118901		￥1950.00	杭州北京（现货）
Bellancom-118901		￥3100.00	杭州北京（现货）

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Opipramol 奥匹哌醇; Ensidon; G-33040

产品介绍

Opipramol (Ensidon) 是一种非典型的三环类抗抑郁试剂 (TCA)。Opipramol 主要用作 sigma (σ) 受体激动剂，可以有效地与 sigma 识别位点相互作用，K_i 值为 50 nM。Opipramol 可用于广泛性焦虑症（GAD）的研究。

生物活性

Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a K_i value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD).

体外研究

Opipramol can potently interact with sigma recognition sites with a K_i value of 50 nM.
Opipramol inhibit the uptake of [³H] DA in crude synaptosomal preparations with an IC₅₀ value of 5.5 μM.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Opipramol (i.p.; 5-50 mg/kg) increases dopamine release in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague-Dawley rats (male, 150-l 80 g)
Dosage:	5-50 mg/kg
Administration:	Intraperitoneal injections
Result:	Increased the levels of DOPAC and HVA in the striatum of the rat, without changing the steady-state levels of DA. Potently increased the metabolism of dopamine in the striatum, olfactory tubercle and pyriform cortex of the rat. Increased plasma prolactin in the rat, only at a dose as large as 50 mg/kg dose.

体内研究

Opipramol (i.p.; 5-50 mg/kg) increases dopamine release in vivo.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Sprague-Dawley rats (male, 150-l 80 g)
Dosage:	5-50 mg/kg
Administration:	Intraperitoneal injections
Result:	Increased the levels of DOPAC and HVA in the striatum of the rat, without changing the steady-state levels of DA. Potently increased the metabolism of dopamine in the striatum, olfactory tubercle and pyriform cortex of the rat. Increased plasma prolactin in the rat, only at a dose as large as 50 mg/kg dose.

性状

Solid

溶解性数据

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

参考文献

. H J Möller, et al. Opipramol for the treatment of generalized anxiety disorder: a placebo-controlled trial including an alprazolam-treated group. J Clin Psychopharmacol. 2001 Feb;21(1):59-65. [Content Brief]

. T S Rao, et al. Neurochemical characterization of dopaminergic effects of opipramol, a potent sigma receptor ligand, in vivo. Neuropharmacology. 1990 Dec;29(12):1191-7. [Content Brief]

化学品安全说明书(MSDS)

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质检证书(COA)

产品编号(Item Number)

批号(Lot Number)

符号	GHS07, GHS09
信号词	Warning
危害声明	H302-H410
警示性声明	P273-P501
危害码 (欧洲)	Xn,N
风险声明 (欧洲)	22-50/53
安全声明 (欧洲)	60-61
危险品运输编码	UN 3077 9 / PGIII
RTECS号	TL8750000
海关编码	2933990090

Opipramol 奥匹哌醇; Ensidon; G-33040,99.0%

Opipramol 奥匹哌醇; Ensidon; G-33040

化学品安全说明书(MSDS)

质检证书(COA)

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