JHU37152|cas:2369979-67-7|西域试剂

JHU37152,98.75%

产品编号：Bellancom-131891| CAS NO：2369979-67-7| 分子式：C₁₉H₂₀ClFN₄| 分子量：358.84

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货号	价格	库存与货期
Bellancom-131891	￥200.00	杭州北京（现货）
Bellancom-131891	￥310.00	杭州北京（现货）
Bellancom-131891	￥620.00	杭州北京（现货）
Bellancom-131891	￥960.00	杭州北京（现货）
Bellancom-131891	￥1580.00	杭州北京（现货）

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JHU37152

产品介绍

JHU37152 是一种有效和可透过血脑屏障的 DREADD 激动剂，对 hM3Dq 和 hM4Di DREADDs 的 EC₅₀ 值分别为 5 nM 和 0.5 nM。JHU37152 在小鼠脑组织中表现出来自 DREADDs 的选择性 [³H]Clozapine 置换作用，而不来自其他 Clozapine 结合部位。

生物活性

JHU37152 is a potent and brain-penetrant DREADD agonist, with EC₅₀s of 5 nM and 0.5 nM for hM3Dq and hM4Di DREADDs in HEK-293 cells, respectively. JHU37152 exhibits selective [³H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites in mice brain tissue.

体外研究

JHU37152 displays high DREADD affinity, with K_is of 1.8 nM and 8.7 nM for hM3Dq and hM4Di expressed in mouse brain sections.
JHU37152 (1-1000 nM) selectively displaces [³H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

JHU37152 (0.1 mg/kg; i.p.) exhibits high DREADD occupancy in mice and rats.
JHU37152 (0.01-1 mg/kg; i.p.) selectively inhibits locomotor activity in D1-hM3Dq and D1-hM4Di mice without any significant locomotor effects observed in WT mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 33.33 mg/mL (92.88 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.7868 mL	13.9338 mL	27.8676 mL
5 mM	0.5574 mL	2.7868 mL	5.5735 mL
10 mM	0.2787 mL	1.3934 mL	2.7868 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式