NS1652|cas:1566-81-0|西域试剂

NS1652,99.89%

产品编号：Bellancom-100244| CAS NO：1566-81-0| 分子式：C₁₅H₁₁F₃N₂O₃| 分子量：324.25

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货号	价格	库存与货期
Bellancom-100244	￥1000.00	杭州北京（现货）
Bellancom-100244	￥2200.00	杭州北京（现货）
Bellancom-100244	￥3500.00	杭州北京（现货）
Bellancom-100244	￥6600.00	杭州北京（现货）

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NS1652

产品介绍

NS1652 是一种可逆的阴离子电导 (anion conductance) 抑制剂，在人和小鼠的红细胞中，可以抑制氯离子通道 (chloride channel)，IC₅₀ 值为 1.6 μM。

生物活性

NS1652 is a reversible anion conductance inhibitor, blocks chloride channel, with an IC₅₀ of 1.6 μM in human and mouse red blood cells.

体外研究

NS1652 potently inhibits the chloride conductance (IC₅₀, 1.6 μM) in human and mouse red blood cells, but only weakly inhibits VRAC (IC₅₀, 125 μM) in HEK293 cells. NS1652 markedly blocks the NO production with an IC₅₀ of 3.1 μM in BV2 cells. NS1652 also down-regulates iNOS expression at 3 μM, and completely abolishes at 10 μM in BV2 cells. NS1652 (0, 1.0, 3.3, 10, and 20 μM) causes increasing hyperpolarization due to inhibition of the chloride conductance in normal erythrocytes. NS1652 lowers the net KCl loss from deoxygenated sickle cells from about 12 mM cells/h to about 4 mM cells/h. NS1652 (20 μM) completely and reversiblely inhibits the red cell Cl^-conductance.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

NS1652 (50 mg/kg, i.v.) blocks murine erythrocyte Cl^- conductance by >90% in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

NS1652 (50 mg/kg, i.v.) blocks murine erythrocyte Cl^- conductance by >90% in mice.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 5 mg/mL (15.42 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.0840 mL	15.4202 mL	30.8404 mL
5 mM	0.6168 mL	3.0840 mL	6.1681 mL
10 mM	0.3084 mL	1.5420 mL	3.0840 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式