Pozanicline dihydrochloride ABT-089 dihydrochloride|cas:161416-61-1|西域试剂

Pozanicline dihydrochloride ABT-089 dihydrochloride,97.96%

产品编号：Bellancom-110160| CAS NO：161416-61-1| 分子式：C₁₁H₁₈Cl₂N₂O| 分子量：265.18

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货号	价格	库存与货期
Bellancom-110160	￥1500.00	杭州北京（现货）
Bellancom-110160	￥2400.00	杭州北京（现货）
Bellancom-110160	￥7800.00	杭州北京（现货）
Bellancom-110160	￥12500.00	杭州北京（现货）

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Pozanicline dihydrochloride ABT-089 dihydrochloride

产品介绍

Pozanicline dihydrochloride (ABT-089 dihydrochloride) 是一种具有口服活性的烟碱型乙酰胆碱受体 (nAChR) 激动剂，与 [³H] 胱氨酸位点结合，K_i 为 16.7 nM。Pozanicline dihydrochloride 是一种 α4β2 选择性 nAChR 激动剂，与大鼠脑 α4β2 nAChR 结合，K_i 为 17 nM，而与 α7nAChR 的结合力很弱。

生物活性

Pozanicline dihydrochloride (ABT-089 dihydrochloride) is an orally bioavailable nicotinic acetylcholine receptor (nAChR) agonist with a K_i of 16.7 nM for binding to [³H]cytisine sites. Pozanicline is an α4β2-selective nAChR agonist, which binds to rat brain α4β2 nAChR with a K_i of 17 nM while binding to α7 nAChR is insignificant.

体外研究

Pozanicline (ABT-089) is a partial agonist at α4β2 nAChR. Moreover, one α6β2 nAChR subtype is particularly sensitive to Pozanicline with an EC₅₀ of 0.11 μM.
Pozanicline (ABT-089) shows high selectivity for α6β2 and α4α5β2 nAChR subtypes.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

Pozanicline (ABT-089; 0.3 mg/kg and 0.6 mg/kg) reverses nicotine withdrawal-induced deficits in contextual fear conditioning.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male C57BL6/J mice at 8-12 weeks of age.
Dosage:	0.3 mg/kg and 0.6 mg/kg
Administration:	Treated 5 min before training and testing for contextual fear conditioning
Result:	A dose of 0.3 mg/kg and 0.6 mg/kg ameliorated nicotine withdrawal-induced cognitive deficits in contextual fear conditioning.

体内研究

Pozanicline (ABT-089; 0.3 mg/kg and 0.6 mg/kg) reverses nicotine withdrawal-induced deficits in contextual fear conditioning.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Adult male C57BL6/J mice at 8-12 weeks of age.
Dosage:	0.3 mg/kg and 0.6 mg/kg
Administration:	Treated 5 min before training and testing for contextual fear conditioning
Result:	A dose of 0.3 mg/kg and 0.6 mg/kg ameliorated nicotine withdrawal-induced cognitive deficits in contextual fear conditioning.

性状

Solid

溶解性数据

In Vitro:

H₂O : 100 mg/mL (377.10 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.7710 mL	18.8551 mL	37.7102 mL
5 mM	0.7542 mL	3.7710 mL	7.5420 mL
10 mM	0.3771 mL	1.8855 mL	3.7710 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶