Pregnenolone-d<sub>4</sub>-1 3β-Hydroxy-5-pregnen-20-one-d<sub>4</sub>-1|cas:61574-54-7|西域试剂

Pregnenolone-d₄-1 3β-Hydroxy-5-pregnen-20-one-d₄-1,98.0%

产品编号：Bellancom-B0151S2| CAS NO：61574-54-7| 分子式：C₂₁H₂₈D₄O₂| 分子量：320.50

孕烯醇酮-d4-1（3β-羟基-5-孕烯醇-20-酮-d4-1）是氘标记的孕烯醇酮。孕烯醇酮（3β-羟基-5-孕烯醇-20-酮）是一种功能强大的神经甾体，是包括甾体酮在内的各种甾体激素的主要前体。孕烯醇酮作为大麻素CB1受体的信号特异性抑制剂，抑制由CB1受体介导的四氢大麻素（THC）的作用。孕烯醇酮可以保护大脑免受大麻中毒。孕烯醇酮也是TRPM3通道激活剂，也能弱激活TRPM1通道。

本网站销售的所有产品仅用于工业应用或者科学研究等非医疗目的,不可用于人类或动物的临床诊断或者治疗,非药用,非食用，

货号	包装	价格	库存与货期	购买量	操作

增值税发票√顺丰快递√订货电话：18601927057

Pregnenolone-d₄-1 3β-Hydroxy-5-pregnen-20-one-d₄-1

产品介绍

Pregnenolone-d₄-1 是一种氘代标记的 Pregnenolone。Pregnenolone (3β-Hydroxy-5-pregnen-20-one) 是一种功能强大的神经甾体，是包括甾体酮在内的各种甾体激素的主要前体。Pregnenolone 是大麻素 CB1 受体的信号传导特异性抑制剂，抑制由 CB1 受体介导的四氢大麻酚 (THC) 的作用。Pregnenolone 可以保护大脑免受大麻中毒。Pregnenolone 也是一种 TRPM3 通道激活剂，也可以弱激活 TRPM1 通道。

生物活性

Pregnenolone-d₄-1 is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels.

体外研究

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

性状

Solid

溶解性数据

In Vitro:

DMSO : 31.25 mg/mL (97.50 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.1201 mL	15.6006 mL	31.2013 mL
5 mM	0.6240 mL	3.1201 mL	6.2402 mL
10 mM	0.3120 mL	1.5601 mL	3.1201 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

参考文献

. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

. Vallée M, et al. Pregnenolone can protect the brain from cannabis intoxication. Science. 2014 Jan 3;343(6166):94-8. [Content Brief]

. Ducharme N, et al. Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration. Eur J Pharmacol. 2010 Sep 1;641(2-3):128-34. [Content Brief]

[4]. Alan Shiels. TRPM3_miR-204: a complex locus for eye development and disease. Hum Genomics. 2020 Feb 18;14(1):7. [Content Brief]

化学品安全说明书(MSDS)

下载MSDS

质检证书(COA)

产品编号(Item Number)

批号(Lot Number)

上游产品 0
下游产品 2
1112-02-3 53-43-0

Pregnenolone-d4-1 3β-Hydroxy-5-pregnen-20-one-d4-1,98.0%

Pregnenolone-d4-1 3β-Hydroxy-5-pregnen-20-one-d4-1

化学品安全说明书(MSDS)

质检证书(COA)

在线咨询

Pregnenolone-d₄-1 3β-Hydroxy-5-pregnen-20-one-d₄-1,98.0%

Pregnenolone-d₄-1 3β-Hydroxy-5-pregnen-20-one-d₄-1