GSK-269984A|cas:892664-04-9|西域试剂

GSK-269984A,99.74%

产品编号：Bellancom-14467| CAS NO：892664-04-9| 分子式：C₂₀H₁₄Cl₂FNNaO₃| 分子量：429.22

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-14467		￥4500.00	杭州北京（现货）
Bellancom-14467		￥8000.00	杭州北京（现货）

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GSK-269984A

产品介绍

GSK-269984A 是前列腺素 E2 受体 1 (Prostaglandin E2 Receptor 1 (EP1)) 的拮抗剂，pIC₅₀ 值为 7.9。

生物活性

GSK-269984A is a Prostaglandin E2 Receptor 1 (EP1) antagonist with a pIC₅₀ of 7.9.

体外研究

Results from [³H]-PGE₂ binding assay in CHO cells overexpressing the human EP₁ receptor demonstrate that GSK-269984A is an antagonist of EP₁ receptor with a pIC₅₀ of 7.9. GSK-269984A is found to cause a concentration-dependent rightward shift of the PGE₂ dose-response curve and Schild analysis shows that GSK-269984A is a competitive antagonist with pA₂ 8.1±0.3 and slope 1.0.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

GSK-269984A demonstrates an ED₅₀ of 2.6 mg/kg (po), with the 10 mg/kg dose showing equivalent reversal of hypersensitivity to the standard. GSK-269984A displays moderate blood clearance in the rat and dog and high clearance in the monkey which is reflected in the half-life for each species.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

性状

Solid

溶解性数据

In Vitro:

DMSO : 7 mg/mL (16.31 mM; ultrasonic and warming and heat to 60°C)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.3298 mL	11.6490 mL	23.2981 mL
5 mM	0.4660 mL	2.3298 mL	4.6596 mL
10 mM	0.2330 mL	1.1649 mL	2.3298 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式