FPR2 agonist 2|cas:2829263-20-7|西域试剂

FPR2 agonist 2,99.59%

产品编号：Bellancom-144604| CAS NO：2829263-20-7| 分子式：C₂₅H₂₀F₂N₄O₂| 分子量：446.45

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货号	价格	库存与货期
Bellancom-144604	￥1500.00	杭州北京（现货）
Bellancom-144604	￥2500.00	杭州北京（现货）
Bellancom-144604	￥5500.00	杭州北京（现货）
Bellancom-144604	￥9500.00	杭州北京（现货）

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FPR2 agonist 2

产品介绍

FPR2 agonist 2 是一种有效的可透过血脑屏障的 FPR2 激动剂，h-FPR2 的 EC₅₀ 值为 0.13 µM。FPR2 agonist 2 抑制促炎细胞因子的产生，抵消线粒体功能的变化，并抑制 caspase-3 的活性。

生物活性

FPR2 agonist 2 is a potent and permeates the blood−brain barrier FPR2 agonist with an EC₅₀ of 0.13 µM, 1.1 µM for FPR2 and FPR1, respectively. FPR2 agonist 2 inhibits the production of pro-inflammatory cytokines, counterbalances the changes in mitochondrial function, and inhibits caspase-3 activity.

体外研究

FPR2 agonist 2 (compound (S)-11l) (1-100 µM; 48 h) exhibits low cytotoxicity with an EC₅₀ value of 20.8 µM in N9 cells.
FPR2 agonist 2 (FPR1/FPR2 HL60 cells) shows agonist activity with EC₅₀s of 0.13 µM, 1.1 µM (IC₅₀s of 0.085 µM, Not determined) for FPR2 and FPR1, respectively.
FPR2 agonist 2 (0.1 µM) effectively blocks LPS-induced cell death and NO production and effectively suppresses the effect of LPS stimulation.
FPR2 agonist 2 (0.1 µM) counterbalances the changes in mitochondrial function, and inhibits caspase-3 activity.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay

Cell Line:	N9 cells
Concentration:	1-100 µM
Incubation Time:	48 h
Result:	Exhibited low cytotoxicity with an EC₅₀ value of 20.8 µM in N9 cells.

体内研究
(In Vivo)

FPR2 agonist 2 (1 mg/kg for i.v.; 10 mg/kg for i.p.) shows the ability to permeate the blood−brain barrier and to accumulate in the brain.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	25-30 g, male CD-1 mice
Dosage:
Administration:	1 mg/kg for i.v.; 10 mg/kg for i.p. (dissolved in 5% DMSO, 10% solutol HS 15, and 85% sterile water)
Result:	Showed the ability to permeate the blood−brain barrier and to accumulate in the brain.

体内研究

FPR2 agonist 2 (1 mg/kg for i.v.; 10 mg/kg for i.p.) shows the ability to permeate the blood−brain barrier and to accumulate in the brain.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	25-30 g, male CD-1 mice
Dosage:
Administration:	1 mg/kg for i.v.; 10 mg/kg for i.p. (dissolved in 5% DMSO, 10% solutol HS 15, and 85% sterile water)
Result:	Showed the ability to permeate the blood−brain barrier and to accumulate in the brain.

体内研究

FPR2 agonist 2 (1 mg/kg for i.v.; 10 mg/kg for i.p.) shows the ability to permeate the blood−brain barrier and to accumulate in the brain.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	25-30 g, male CD-1 mice
Dosage:
Administration:	1 mg/kg for i.v.; 10 mg/kg for i.p. (dissolved in 5% DMSO, 10% solutol HS 15, and 85% sterile water)
Result:	Showed the ability to permeate the blood−brain barrier and to accumulate in the brain.