DA-JC4|cas:2315504-40-4|西域试剂

DA-JC4,96.57%

产品编号：Bellancom-P3255| CAS NO：2315504-40-4| 分子式：C₂₂₅H₃₄₆N₅₆O₆₅| 分子量：4875.49

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货号	包装	价格	库存与货期	购买量	操作
Bellancom-P3255		￥9500.00	杭州北京（现货）

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DA-JC4

产品介绍

DA-JC4 是一种双 GLP-1/GIP receptor 激动剂，可用于神经系统疾病和胰岛素信号通路的研究。

生物活性

DA-JC4 is a dual GLP-1/GIP receptor agonist and can be used for the research of neurological disease and insulin signaling pathways.

体外研究

DA-JC4 (1~100 nM; hippocampal cells) inhibits rotenone-induced hippocampal neuron death and significantly suppresses Cyt C, Bax and Caspase activation.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

DA-JC4 (10 nmol/kg; i.p.; once-daily for 14 days) significantly prevents spatial learning deficits in a Y- maze test and Morris water maze tests, and decreases phosphorylated tau levels in the rat cerebral cortex and hippocampus.
DA-JC4 (25 nmol/kg; i.p.; 6 days) shows high levels expression of tyrosine Hydroxylase in the s. nigra and increases expression of neuroprotective growth factor Glial-Derived Neurotrophic Factor (GDNF).
DA-JC4 (50 nmol/kg; i.p.; once-daily for 7 days) improves Parkinson's disease symptom potentially and enhances neurotransmission.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats (210–230 g)
Dosage:	10 nmol/kg
Administration:	I.p.
Result:	Significantly prevented spatial learning deficits in a Y- maze test and Morris water maze tests, and decreased phosphorylated tau levels in the rat cerebral cortex and hippocampus.

Animal Model:	Adult male C57BL/6 mice (8 week-old)
Dosage:	25 nmol/kg/day
Administration:	I.p.
Result:	Showed high levels expression of tyrosine Hydroxylase in the s. nigra and increased expression of neuroprotective growth factor Glial-Derived Neurotrophic Factor (GDNF).

Animal Model:	Adult male Sprague-Dawley (SD) rats (230-280 g)
Dosage:	50 nmol/kg
Administration:	I.p.
Result:	Improved Parkinson's disease symptom potentially and enhanced neurotransmission.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male Sprague-Dawley rats (210–230 g)
Dosage:	10 nmol/kg
Administration:	I.p.
Result:	Significantly prevented spatial learning deficits in a Y- maze test and Morris water maze tests, and decreased phosphorylated tau levels in the rat cerebral cortex and hippocampus.

Animal Model:	Adult male C57BL/6 mice (8 week-old)
Dosage:	25 nmol/kg/day
Administration:	I.p.
Result:	Showed high levels expression of tyrosine Hydroxylase in the s. nigra and increased expression of neuroprotective growth factor Glial-Derived Neurotrophic Factor (GDNF).

Animal Model:	Adult male Sprague-Dawley (SD) rats (230-280 g)
Dosage:	50 nmol/kg
Administration:	I.p.
Result:	Improved Parkinson's disease symptom potentially and enhanced neurotransmission.