ALX-5407 ((R)-NFPS) hydrochloride is a selective and orally active glycine transporter GlyT1 inhibitor with an IC₅₀ value of 3 nM. ALX-5407 hydrochloride can be used the research of N-methyl-D-aspartate-receptor function and schizophrenia.

ALX-5407 hydrochloride (0-1 mM) GlyT1- 或 GlyT2- 依赖地抑制甘氨酸转运，阻断大鼠大脑和 QT6-1C 细胞中 [³H] 甘氨酸的摄取，IC₅₀ 值为 3 nM。
ALX-5407 hydrochloride (50 nM) 在 QT6-1C 细胞中表现出缓慢的解离动力学。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

ALX-5407 hydrochloride (1 和 10 mg/kg；口服，一次) 增加大鼠前额叶皮层游离甘氨酸水平。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

ALX-5407 hydrochloride (1 和 10 mg/kg；口服，一次) 增加大鼠前额叶皮层游离甘氨酸水平。

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

• . Atkinson BN, et al. ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter. Mol Pharmacol. 2001 Dec;60(6):1414-20.  [Content Brief]