SB-200646A|cas:143797-62-0|西域试剂

SB-200646A,99.47%

产品编号：Bellancom-103129| CAS NO：143797-62-0| 分子式：C₁₅H₁₅ClN₄O| 分子量：302.76

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货号	价格	库存与货期
Bellancom-103129	￥1100.00	杭州北京（现货）
Bellancom-103129	￥1450.00	杭州北京（现货）
Bellancom-103129	￥4800.00	杭州北京（现货）
Bellancom-103129	￥7600.00	杭州北京（现货）

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SB-200646A

产品介绍

SB-200646A 是第一个对 5-HT_2B/2C 的选择性超过 5-HT_2A 的拮抗剂，5-HT_2B，5-HT_2C 和 5-HT_2A 的 pK_i 值分别为 7.5、6.9 和 5.2。SB-200646A 具有口服活性，在体内具有电生理和抗焦虑特性。

生物活性

SB-200646A is the first selective 5-HT_2B/2C over 5-HT_2A receptor antagonist with pK_i values of 7.5, 6.9 and 5.2 for 5-HT_2B, 5-HT_2C and 5-HT_2A, respectively. SB-200646A is orally active and has electrophysiological and anxiolytic properties in vivo.

体外研究

SB200646A (4 μM) abolishes the ethanol-induced increase in miniature inhibitory postsynaptic current (mIPSC) frequency and had no effect on basal mIPSC frequency.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究

SB-200646A (20 mg/kg; intravenous injection; daily; for 21 days; male albino Sprague-Dawley rats) treatment significantly decreases the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons.
The i.v. administration of 4-16 mg/kg of SB-200646A significantly increases the firing rate and % events as bursts in spontaneously active VTA dopaminergic neurons and significantly increases the % events as burst in substantia nigra pars compacta (SNC) dopaminergic neurons.

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male albino Sprague-Dawley rats (200-225 g at the beginning of treatment and 300-350 g at the time of the experiment)
Dosage:	20 mg/kg
Administration:	Intravenous injection; daily; for 21 days
Result:	Significantly decreased the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons.

体内研究

西域 has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male albino Sprague-Dawley rats (200-225 g at the beginning of treatment and 300-350 g at the time of the experiment)
Dosage:	20 mg/kg
Administration:	Intravenous injection; daily; for 21 days
Result:	Significantly decreased the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons.

性状

Solid

溶解性数据

In Vitro:

DMSO : 250 mg/mL (825.74 mM; Need ultrasonic)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	3.3029 mL	16.5147 mL	33.0295 mL
5 mM	0.6606 mL	3.3029 mL	6.6059 mL
10 mM	0.3303 mL	1.6515 mL	3.3029 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

参考文献